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GSK3 beta Inhibitor TDZD-8

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Looking for an inhibitor of glycogen synthase kinase-3 (GSK3) beta?
TDZD-8 was found to be a key intermediate in apoptotic signaling associated with neurodegenerative diseases such as Parkinsons.

The thiadiazolidine, TDZD-8, is an inhibitor of the pro-apoptotic protein GSK-3β (Glycogen synthase kinase 3β). GSK-3β is abundant in the nervous system, in particularly the hippocampus and plays an important role in numerous diseases including Parkinson’s disease and Alzheimer’s disease. TDZD-8 has been used to study GSK-3β in order to determine the effects of α-synuclein, a tau protein hyperphosphorylator, upon Parkinson’s disease and Alzheimer’s disease initiation. TDZD-8 also mechanism to target malignant and progenitor populations.

Biomol offer TDZD-8 from LKT Labs at a very competitive price.

General References:
1. Chen G, Bower KA, Ma C et al. FASEB J. 18:1162-1164 (2004).;
2. Barry FA, Graham GJ, Fry MJ et al. FEBS letters. 553:173-178 (2003).

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