Imgenex Caspase Promotion

Selected Imgenex products for caspase research.

Caspases: New Roles for Necroptosis & Immunity Programmed Pathways

Beyond their well-studied role as mediators of apoptotic programs, caspase participation in regulation of additional cellular pathways is now being characterized in a variety of far-ranging cellular processes. In regulation of innate immunity, caspase-8 has been implicated in regulation of pro-inflammatory cytokines, in adaptive immunity in T-cell proliferation, and in preventing NECROPTOSIS, an emerging necrotic cell death pathway, among other activities^1-2. Caspase-mediated induction of apoptosis may in fact also lead to compensatory proliferation³. Caspases are also being studied in cell differentiation mechanisms related to a number of cells including stem cells, where caspase-3 cleavage of Nanog, a master transcription factor needed for self-renewal, may lead instead to differentiation⁴. Caspase-11, especially, and caspase-1 appear to function in regulating cell migration and motility through actin formation and polymerization or actin dynamics^5-6.

IMGENEX provides leading edge products including inhibitors, antibodies, and other tools for studying caspases and pathway related molecules. In addition, IMGENEX provides the widest array of antibodies characterized for recognition of pro- and cleaved forms of caspases.

Find here key kits, individual antibodies and reagents to promote study of caspase functions in pathways in a wide range of experimental systems including the newly defined Necroptosis process.

View References

Structure of Caspases

Caspase Antibody Sampler Kit, Cat. No. IMG-253K

Cat. No.	Specificity	Immunogen (A.A.)	Reactivity	Application
IMG-5028	Caspase-1	371 RKVRFSFEQPDGRAQMPTTE 390	H, M	WB, IHC-P
IMG-585	Caspase-2	400 REGYAPGTEFHRC 412	H	WB
IMG-144A	Caspase-3 (Pro and Active / Cleaved)	Localized to the large domain subunit	H, M, R	WB, IHC-P, IHC-Fr
IMG-145	Caspase-3 (Pro and Active / Cleaved)	Recombinant Caspase-3 protein	H	WB
IMG-5701	Caspase-6 (Pro and Active / Cleaved)	Recombinant catalytically active protein	H, M, R, D, G	WB, IHC-P, IHC-Fr
IMG-277	Caspase-7 (Pro and Active / Cleaved)	Recombinant Caspase-7 protein	H, M, R	WB
IMG-274A	Caspase-8 (Pro and Active / Cleaved)	370 PVETDSEEQP 379	H, Ch, Rh	WB
IMG-5705	Caspase-9	Recombinant catalytically active protein	H, M, R	WB, IHC, IP, Immuno-EM
IMG-4150	Caspase-10	1 MKSQGQHWYSSSDKN 15	H, M, R, C	WB
IMG-5713	Caspase-14	2 ESEMSDPQPLQEERYDM 18	H, M, R, D, G	WB, IHC, IP

Caspase Inhibitors

Cat. No.	Description
IMI-2310	Broad-Spectrum Caspase Inhibitor: Z-VAD-FMK
IMI-2311	Broad-Spectrum Caspase Inhibitor: BOC-D-FMK
IMI-2309	Broad-Spectrum Caspase Inhibitor: Q-VD-OPH
IMI-2312	Caspase-3/7 Inhibitor: Z-DEVD-FMK
IMI-2313	Caspase-8 Inhibitor: Z-IETD-FMK
IMI-2314	Caspase-9 Inhibitor: Z-LEHD-FMK
IMI-2315	FAM Caspase Activity Kit
IMI-2316	SR Caspase Activity Kit
IMI-2318	Z-FA-FMK:Caspase Inhibitor Negative Control

Caspase Antibodies

Cat. No.	Description	Format	Reactivity	Clone	Application
IMG-3078	ASC/TMS	P, AP	H	N/A	ELISA, WB
ABU007	CARMA1/CARD11 Ab Bundle	Sera	H	N/A	Peptide ELISA
IMG-5025	Caspase-1	Purified	H	N/A	IHC-P, WB
IMG-5028	Caspase-1	Purified	H, M	14F468	IHC-P, WB
IMG-80402	Caspase-1	Purified	H, M, R	N/A	IHC-P
IMG-585	Caspase-2	Ascites	H	18E809.3	WB
IMG-5557	Caspase-2 (NT)	P, AP	H, M	N/A	IF/ICC, WB
IMG-80215	Caspase-3	Purified	H	3CSP03	IHC-Fr, IHC-P, IP, WB
IMG-80432	Caspase-3	Purified	Multiple	N/A	IHC-P
IMG-5700	Caspase-3 (Active/Cleaved)	Sera	Multiple	N/A	IHC-Fr, IHC-P, IP, WB
IMG-144A	Caspase-3 (Pro and Active)	Purified	H, M, R	31A1067	IHC-Fr, IHC-P, WB
IMG-5558	Caspase-4 (NT)	P, AP	H	N/A	IHC-P, WB
IMG-5439	Caspase-5 (IN)	P, AP	H	N/A	WB
IMG-5701	Caspase-6 (Active/Cleaved)	Sera	Multiple	N/A	IHC-Fr, IHC-P, IP, WB
IMG-277	Caspase-7 (Pro and Active)	Purified	H, M, R	25B881.1	WB
IMG-274A	Caspase-8	Purified	H, Ch, Rh	90A992	IHC-P, WB
IMG-131	Caspase-9	Purified	H	N/A	WB
IMG-5706	Caspase-9	Sera	Multiple	N/A	IHC-Fr, IHC-P, IP, WB
IMG-4150	Caspase-10	Purified	Multiple	N/A	WB
IMG-5710	Caspase-10	Sera	Multiple	N/A	IHC-Fr, IHC-P, IP, WB
IMG-300	Caspase-12	Purified	H, M, R	N/A	IHC-P, WB
IMG-5556	Caspase-12 (lrg)	P, AP	H, M, R	N/A	IHC-P, WB
IMG-167	Caspase-14	Purified	M	70A1426	WB
IMG-5713	Caspase-14	Sera	Multiple	N/A	IHC-Fr, IHC-P, IP, WB

RNA Interference Kits

Caspase-1 shRNA
Caspase-8 shRNA
Caspase-9 shRNA
Caspase-9 siRNA plus Antibody

References

¹Zhang, J., Cado, D., Chen, A., Kabra, N.H., and Winoto, A. (1998). Fas-Mediated apoptosis and activation-induced T-Cell proliferation are defective in maic lacking FADD/Mort1. Nature 392, 295-300
²DegterevA. Huang, Z.., Boyce, M., Li, Y.., Jagtap, P. Mizuchima, N., Cuny, G.D., Mitchison, T.J. Moskowitz, M.A., and Yuan, J. (2005). Chemical Inhibitor, of nonapoptotic cell death, with therapeutic potential for ischemic brain injury. Nat. Chem. Biol. 1., 112-119.³Stoick-Cooper, C.L>, Moon, R.T., and Weidinger, G. (2007). Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes Dev. 21, 1292-1315.⁴Fujita, A., Crane, A.m., Souza, M.K., Dojosez, M., Kyba, M., Flavell, R.A., Thomson, J.A., and Zwaka, T.P. (2008). Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell 2, 595-601.⁵Li, J., Bieher, W.M, Scimone, M.L, Kang, S.J., Zhu, H., Yin, H., von Andrian, U.H., Mitchison, T., and Yuan, J. (2007). Caspase-11 regulates cell migration by promoting Aip-1-Cofilin mediated actin depolymerization. Nat Cell Biol. 9, 276-286.

⁶Li, J., Yin, H.L., and Yuan, J. (2008). Flightless-1 regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity. J. Cell. Biol. 818, 321-333.

This special discount cannot be applied together with other discounts. It is valid for customers in Germany.
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