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HDAC and Dnmt Antibodies

Key HDAC and Dnmt Antibodies for Cell Regulation.
Histone deacetylases exert transciptional control through deacetylation of core histone proteins. DNA methyltransferases regulate gene expression through cytosine methylation. Changes in methylation patterns have been linked with neoplasia development.

HDAC Antibodies
HDAC-1 HDAC-6
HDAC-2 (Ab-394) HDAC-7
HDAC-3 HDAC-7 (Ser155)
HDAC-4 HDAC-7 (Ser318)
HDAC-4 (Ab-632) HDAC-7 (Ser448)
HDAC-4 (Ser632) HDAC-8 (Ab-39)
HDAC-5 HDAC-8 (Ser39)
HDAC-5 (Ab-498) HDAC-9
HDAC-5 (Ser498)  
 
Dnmt Antibodies
Dnmt1
Dnmt2
Dnmt3a
Dnmt3b
 

Reference:
Stage-specific induction of DNA methyltransferases in olfactory receptor neuron development.
Jessica L. MacDonald, Christopher S.Y. Gin and A. Jane Roskams. Developmental Biology, 288 (2): 461-473 (2005).
 
 
Dnmt3a, IMG-268A

Expression of Dnmt3a in the nuclei of post-mitotic neurons in the olfactory epithelium (OE). DNMT3a (red) is co-expressed with neuron-specific tubulin (green) throughout the development of the olfactory epithelium, using IMG-268A. (Data courtesy of A. Jane Roskams, University of British Columbia).

HDAC-7 (Ser155), IMG-6125A

Western blot analysis of phosphorylated HDAC-7 in (A) recombinant fusion protein containin a phosphorylated serine at position 155 and (B) fusion protein containing an unphosphorylated serine at position 155, using IMG-6125A at 0.1 ug/ml.


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