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More Efficient Hematopoietic Stem Cell Expansion

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More efficient expansion of human hematopoietic stem cells with recombinant FLT3 Ligand (HuXp).
FLT3 ligand (FLT3L) is a growth factor that regulates profileration of early hematopoietic cells. HumanZyme has produced FLT3L (HuXp) in a stable proprietary human 293 cell expression system. The protein is a glycosylated monomer of 24-30 kD. This is narrower range than reported for this cytokine when expressed in insect Sf21 cells (17-30kD), emphasizing the qualitative difference in glycosylation of the expression systems. The bioactivity of FLT3L, shown in the chart below, was determined by the expansion of human CD34+ cells at 10 ng/ml and in the presence of 100ng SCF. The results indicate FLT3L (HuXp) is substantially more active than the insect cell expressed protein, suggesting that FLT3L (HuXp) is a superior and cost-effective cytokine for application to hematopoietic stem cells. (The data was provided by an independant laboratory working in the field of stem cell therapeutics.) This product adds to the rapidly expanding range of stem cell related cytokines available from HumanZyme Inc., manufactured to high quality standards and providing high biological activity, lot-to-lot consistency and low endotoxin levels.

Authentic recombinant human cytokines - human cell expressed ...

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