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Oxidative Stress and Cancer

Results of recent publications.
F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage (Nature, June 2009). Bmi1 regulates mitochondrial function and the DNA damage response pathway (Nature, May 2009).

Artemis is a multifunctional phospho-protein with roles in DNA repair and regulation of cell-cycle checkpoints after DNA damage. Artemis is a negative regulator of p53 in response to oxidative stress (Oncogene, June 2009).

Sustained p62 (SQSTM1) expression resulting from autophagy defects was sufficient to alter NFkB regulation and gene expression and to promote tumorigenesis (Cell, June 2009).



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