Oxidative Stress and Cancer
Results of recent publications.
F-box protein FBXO31
mediates cyclin D1 degradation to induce G1 arrest after DNA damage (Nature, June 2009
regulates mitochondrial function and the DNA damage response pathway (Nature, May 2009
is a multifunctional phospho-protein with roles in DNA repair and regulation of cell-cycle checkpoints after DNA damage. Artemis is a negative regulator of p53 in response to oxidative stress (Oncogene, June 2009
) expression resulting from autophagy
defects was sufficient to alter NFkB regulation and gene expression and to promote tumorigenesis (Cell, June 2009