Cytokines are signaling proteins in cellular communication.
While hormones are secreted from specific organs to the blood, and neurotransmitters are related to neural activity, the cytokines are a more diverse class of compounds in terms of origin and purpose. They are produced by a wide variety of hematopoietic and non-hematopoietic cell types and can have autocrine, paracrine and endocrine effects, sometimes strongly dependent on the presence of other chemicals. The cytokine family consists mainly of smaller, water-soluble proteins and glycoproteins with a mass between 8 and 30 kDa.
The term cytokine is used generically for interleukins, chemokines, growth factors, neurotrophins and similar extracellular proteinaceous ligands (lymphokines, monokines, interferons, colony-stimulating factors, immunomodulators, immunotransmitters, etc.).
Cytokines can be isolated from natural sources or are recombinant and produced in bacteria, yeast or higher eukaryotic cells. Wheras bacterially expressed ones lack post-translational modifications, the latter are glycoproteins. In many assays non-glycosylated cytokines show a similar activity as glycosylated ones, for some studies glycosylation is important.
Cytokine Product Line
Biomol, Imgenex, Kingfisher, BPS, USBio, AdipoGen, and Humanzyme produce more than 1000 cytokines, all available from Biomol .
At Biomol you find this extensive range of cytokines:
Alphabetic Listing of Cytokines
4, A, B, C, E, F, G, H, I, K, L, M, N, O, P, R, S, T, V.
New: Clean and glycosylated cytokines (very low endotoxin) expressed in plants (barley grain): bio-clean cytokines.
About 400 of Biomols cytokines are presented in this pdf document (102 kB).
New: Biomol offers a range of human cytokines, which have been recombinantly produced in human cell lines. They carry authentic glycosyslation making them more stable and active:
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HumaXPress Human Cell Line Expressed Cytokines
Cytokine and Ligand ELISA Kits
Biomol offers a selection of affordable and easy-to-use ELISA kits for determination of concentration cytokines (and similar ligands).
Biomol offers also thousands of antibodies for the analysis of cytokines and similar ligands.
Find your cytokine here ...