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IBMX
IBMX

Item number: Cay13347-100

IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 µM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP...
Keywords: 1-Methyl-3-Isobutylxanthine, Isobutylmethylxanthine, NSC 165960, SC-2964,...
Application: PDE inhibitor
CAS 28822-58-4
MW: 222.3 D
From 50.00€ *
Review
Penitrem A
Penitrem A

Item number: Cay11347-1

Penitrem A is a tremorgenic fungal toxin that acts as an inhibitor of large-conductance calcium-activated potassium channels KCa1.1/BK, inhibiting the binding of charybdotoxin with an IC50 value of 1.7 µM. It is currently used to evaluate the role of KCa1.1-mediated potassium flux in various cell processes and...
Keywords: NSC 354845, Tremortin A,...
Application: BKCa inhibitor
CAS 12627-35-9
MW: 634.2 D
From 56.00€ *
Review
Anti-SIRT7
Anti-SIRT7

Item number: Cay13477-1

SIRT7 is a member of a famiy of proteins called sirtuins (SIR2-like proteins) and are present in prokaryotes and eukaryotes. All SIR2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast, and mammalian sirtuins...
Keywords: Silent Information Regulator 7, SIR2, Sirtuin 7
Application: WB
Host: Rabbit
Species reactivity: human
432.00€ *
Review