11 products were found matching "Cay10007542"!

Vinclozolin M2 is an active metabolite of vinclozolin (Cay-23939). It is formed from vinclozolin by successive esterase activity and decarboxylation of vinclozolin in C. elegans and by decarboxylation in human liver microsomes. Vinclozolin M2 is an antagonist of the mineralocorticoid receptor (IC50 = 1,400 nM) and...

Docosahexaenoic Acid (DHA) is an essential fatty acid and the most abundant omega-3 fatty acid in neural tissues, especially in the retina and brain. Docosahexaenoyl ethanolamide (DHEA) is the ethanolamine amide of DHA that has been detected in both brain and retina at concentrations similar to those for...

N-Arachidonoyl-L-serine-d8 (ARA-S-d8) contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of ARA-S (Cay-10005455) by GC- or LC-mass spectrometry. Arachidonoyl amides of both amino acids and neurotransmitters such as...

Prostaglandin F2alpha (PGF2alpha), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. Both 17-phenyl trinor PGF2alpha and 16-phenoxy tetranor PGF2alpha are metabolically stable analogs of PGF2alpha and potent agonists for the FP receptor. 17-phenoxy trinor...

Sphinganine (d18:0) is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers. Sphinganine can block protein kinase C...

The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression. Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to...

Protein acetylation is a reversible, post-translational modification regulated by lysine acetyltransferases and deacetylases and plays a key role in regulating gene expression. 4-pentynoyl-Coenzyme A (trifluoroacetate salt) (4-pentynoyl-CoA (trifluoroacetate salt)) is an alkyne-derivatized acetyl-CoA reporter that...

Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2alpha) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with...

For use in Cayman's S-Nitrosylated Protein Detection Kit.

Formulation: 120 µl of anti-PPARalpha antibody in TBS, pH 7.4, 50% glycerol and 1% BSA. Origin: Animal/Rabbit, Animal/Bovine.

(S)-Flurbiprofen is the COX-active enantiomer of the non-selective COX inhibitor flurbiprofen (Cay-70250) with IC50 values of 0.48 and 0.47 µM for COX-1 and COX-2, respectively, in guinea pig whole blood. It inhibits the release of 6-keto prostaglandin F1alpha (6-keto-PGF1alpha, Cay-15210) and thromboxane B2 (TXB2,...