Biomol offers a wide range of interferon α, β and γ preparations.
Interferons (IFNs) are proteins made and released by lymphocytes in response to the presence of pathogens.
Cytokines are linked to order information of the relavant cytokines, receptors are linked to order information of the relevant antibodies:
|Cytokine ||Size ||Receptors ||Producer Cells ||Actions |
|IFN-α ||166, monomer ||CD118 (IFNAR2) ||Leukocytes, dendritic cells ||Antiviral, increased MCC class I expression |
|IFN-β ||166, monomer ||CD118 (IFNAR2) ||Fibroblasts ||Antiviral, increased MCC class I expression |
|IFN-γ ||143, homodimer ||CD119 (IFNGR2) ||T cells, natural killer cells ||Macrophage activation, increased expression of MHC molecules and antigen processing components, IG class switching, suppresses Th2 |
belong to class I
of the interferons, IFN-γ
is the member of the class II
of interferons. IL-28
are classified as class III
interferons. These class III IFNs signal through a receptor complex consisting of IL10R2 (also called CRF2-4
or CD210b) and IFNLR1
(also called CRF2-12).
Janeways Immunobiology (7th edition), Kenneth Murphy, Paul Travers, Mark Walport, Garland Science (2008), p. 799