JMJD2A (human, recombinant, Strep-tagged)

JMJD2A (human, recombinant, Strep-tagged)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11299-100 100 µg -

6 - 10 business days*

642.00€
 
Methylation of lysine residues of core histones plays a critical role in the regulation of gene... more
Product information "JMJD2A (human, recombinant, Strep-tagged)"
Methylation of lysine residues of core histones plays a critical role in the regulation of gene expression. Jumonji domain containing 2A (JMJD2A) is the first reported trimethyllysine-specific histone demethylase. It catalyzes the demethylation of trimethylated forms of histone at lysine residues 9 and 36. Like other JmjC protein hydroxylase family members, JMJD2A is an alpha-ketoglutarate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity, therefore this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin. JMJD2A's transcriptional function appears to depend on protein associations, as it is implicated in both transcriptional silencing and upregulation of the androgen receptor-dependent genes. Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylases may be drug discovery targets for therapeutic intervention.Synonyms: JHDM3A, Jumonji Domain Containing 2A, KDM4A, Lysine (K)-specific Demethylase 4A. Purity: >95% estimated by SDS-PAGE. Source: Recombinant N-terminal Strep II-tagged protein expressed in E. coli. Amino Acids: 2-350. MW: 42.7 kDa. Formulation: (Request formulation change), 20 mM HEPES, pH 7.4, and 150 mM NaCl. License: Sold under license from IBA.. UniProt Accession #: O75164.
Keywords: KDM4A, JHDM3A, Lysine-specific demethylase 4A, Lysine-specific demethylase 4A, Jumonji domain-containing protein 2A, Jumonji domain-containing protein 2A, JmjC domain-containing histone demethylation protein 3A, JmjC domain-containing histone demethylatio
Supplier: Cayman Chemical
Supplier-Nr: 11299

Properties

Application: Enzyme activity, WB
Conjugate: No
Host: E.coli
MW: 42,7 kD
Purity: >95% estimated by SDS-PAGE
Format: Solution

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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