9 products were found matching "Cay11070-25"!

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DNA Methyltransferase 3L (human recombinant)
DNA Methyltransferase 3L (human recombinant)

Item number: Cay10770-25

The DNA methyltransferase 3 (DNMT3) family of DNMT proteins establish intial methylation of cytosines to form 5-methylcytosine at CpG (cytosine-phosphate-guanine) sites. Once methylation is established on DNA, DNMT1 protein is responsible for maintaining the CpG methylation pattern during chromosome replication. The...
Keywords: DNMT3L, DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3-like
Application: Methylation studies
MW: 53,2 kD
732.00€ *
Review
AZD 1480
AZD 1480

Item number: Cay10702-5

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). AZD...
Keywords: 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
Application: JAK2 inhibitor
CAS 935666-88-9
MW: 348.8 D
From 50.00€ *
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Bisindolylmaleimide III
Bisindolylmaleimide III

Item number: Cay11072-5

Bisindolylmaleimide III was developed as a protein kinase C (PKC) inhibitor with structural similarity to the nonspecific PKC inhibitor staurosporine. At 1 µM, bisindolylmaleimide III inhibits 93% of PKCalpha kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1 with...
Keywords: BIM III, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Application: PKC inhibitor
CAS 137592-43-9
MW: 384.4 D
From 77.00€ *
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BRD2 bromodomain 2 (human, recombinant)
BRD2 bromodomain 2 (human, recombinant)

Item number: Cay11070-1

Bromodomain-containing 2 (BRD2) is a transcriptional regulator that is a member of the bromodomain and extra-terminal (BET) family. It is ubiquitously expressed and localizes to the nucleus. BRD2 is composed of two N-terminal bromodomains (BD1 and BD2) that bind acetylated lysine on histones, serving to couple...
Keywords: BRD2, O27.1.1, O27.1.1, KIAA9001, Bromodomain-containing protein 2, Bromodomain-containing protein 2, Really interesting...
Expressed in: E.coli
From 378.00€ *
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Bisindolylmaleimide II
Bisindolylmaleimide II

Item number: Cay11020-5

Bisindolylmaleimide II (BIM II) is a general inhibitor of all protein kinase C (PKC) subtypes with structural similarity to the nonspecific PKC inhibitor staurosporine. At 10 µM, BIM II inhibits 98% of PKCalpha kinase activity. Additionally, it inhibits PDK1 (IC50 = 14 µM), an important kinase in the insulin...
Keywords: BIM II, 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Application: PKC inhibitor
CAS 137592-45-1
MW: 438.5 D
From 77.00€ *
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JWH 018 N-(4,5-epoxypentyl) analog
JWH 018 N-(4,5-epoxypentyl) analog

Item number: Cay11075-10

JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively). This cannabimimetic compound has frequently been found in herbal blends. JWH 018 N-(4,5-epoxypentyl) analog is distinguished by a terminal epoxide group on the alkyl...
Keywords: JWH 018 epoxide, naphthalen-1-yl(1-(3-(oxiran-2-yl)propyl)-1H-indol-3-yl)methanone
Application: Analytical reference standard, synthetic cannabinoid analog
CAS 2365471-31-2
MW: 355.4 D
From 109.00€ *
Review
Lipid-based Drug Delivery Tools
1-Stearoyl-2-hydroxy-sn-glycero-3-PC
1-Stearoyl-2-hydroxy-sn-glycero-3-PC

Item number: Cay15107-250

1-Stearoyl-2-hydroxy-sn-glycero-3-PC is a saturated lysophosphatidylcholine. It increases IL-1beta production in isolated human blood monocytes when used at a concentration of 12.5 µM. Plasma levels of 1-stearoyl-2-hydroxy-sn-glycero-3-PC are decreased in patients with lung cancer.Formal Name:...
Keywords: 1-Octadecanoyl-2-hydroxy-sn-glycero-3-phosphatidylcholine, 1-Stearoyl-2-hydroxy-sn-glycero-3-Phosphocholine,...
Application: Lysophosphatidylcholine
CAS 19420-57-6
MW: 523.7 D
From 84.00€ *
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Conessine
Conessine

Item number: Cay11700-250

Conessine is a steroidal alkaloid that has been found in H. antidysenterica and has diverse biological activities. It is active against a variety of Gram-positive and Gram-negative bacteria, including B. subtilis, S. aureus, M. luteus, and E. coli (MICs = 15.6-1,000 µg/disc in agar diffusion assays), the amoeba E....
Keywords: Neriine, NSC 119994, Roquessine, Wrightine, N,N-dimethyl-con-5-enin-3beta-amine
Application: Allergy/Asthma studies
CAS 546-06-5
MW: 356.6 D
From 161.00€ *
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Bucindolol
Bucindolol

Item number: Cay21070-5

Bucindolol is a third-generation, non-selective beta-adrenergic receptor blocker that acts on both beta1 and beta2 receptors. Formulations containing beta-blockers, such as bucindolol, are used in managing chronic heart failure. Bucindolol is also a weak alpha1-adrenoceptor antagonist, which may be linked to a mild...
Keywords: DL-Bucindolol, MJ13105-1, 2-[2-hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]-benzonitrile
Application: beta-adrenergic receptor antagonist
CAS 71119-11-4
MW: 363.5 D
From 60.00€ *
Review