- Search results for Cay10006910
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8 products were found matching "Cay10006910"!
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Item number: Cay10006910-96
The HIF (hypoxia-inducible factor) transcription factor is a member of the basic-helix-loop-helix (bHLH) family of transcription factors and plays an important role in maintaining cellular oxygen homeostasis. HIF-1alpha has emerged as an important drug target in breast and prostate cancer, cardiovascular disease,...
Keywords: | Hypoxia-Inducible Factor-1alpha |
Application: | HIF DNA binding |
Species reactivity: | human, mouse, rat |
661.00€
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Item number: Cay10006999-100
Eicosapentaenoic acid (EPA, Cay-90110) is an omega-3 fatty acid abundantly available in marine organisms. (±)17(18)-DiHETE is one of the major metabolites produced when eicosapentaenoic acid (EPA) is incubated with various rat tissue homogenates or cynomolgus monkey seminal vesicles. The route of production of...
Keywords: | (±)17,18-dihydroxy-eicosa-5,8,11,14-Tetraenoic Acid, (±)17,18-dihydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid |
Application: | Bioactive lipid assays |
MW: | 336.5 D |
From 141.00€
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Item number: Cay10699-10
Adipocyte fatty acid binding protein (A-FABP/aP2) is a carrier protein expressed in both adipocytes and macrophages where it functions in intracellular fatty acid solubilization, trafficking, and metabolism. Molecular disruption of A-FABP/aP2 in mice results in improved insulin sensitivity and protection from...
Keywords: | 4-[(3-carboxy-1-oxo-2-propen-1-yl)amino]-[2,2'-bithiophene]-5-carboxylic acid, 5-methyl ester |
Application: | A-FABP/aP2 antagonist |
CAS | 682741-29-3 |
MW: | 337.4 D |
From 43.00€
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Item number: Cay11069-100
Bromodomain-containing 2 (BRD2) is a transcriptional regulator that is a member of the bromodomain and extra-terminal (BET) family. It is ubiquitously expressed and localizes to the nucleus. BRD2 is composed of two N-terminal bromodomains (BD1 and BD2) that bind acetylated lysine on histones, serving to couple...
Keywords: | BRD2, O27.1.1, O27.1.1, KIAA9001, Bromodomain-containing protein 2, Bromodomain-containing protein 2, Really interesting... |
Application: | Binding studies |
MW: | 71,2 kD |
From 465.00€
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Item number: Cay10006973-10
Pravadoline is a nonacidic, aminoalkylindole analgesic agent that inhibits cyclooxygenase. Like NSAIDs, pravadoline inhibits prostaglandin synthesis (IC50 = 5 µM in mouse brain microsomes) and displays antinociceptive activity (ED50 = 26 mg/kg in an acetylcholine-induced writhing assay in mice). In contrast to...
Keywords: | WIN 48,098, (4-methoxyphenyl)[2-methyl]-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-methanone |
Application: | Analytical reference standard, COX inhibitor, NSAID |
CAS | 92623-83-1 |
MW: | 378.5 D |
From 274.00€
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Item number: Cay10006974-10
AM630 binds selectively to cannabinoid 2 (CB2) over CB1 receptors with Ki values of 31.2 and 5,152 nM, respectively. AM630 acts as an inverse agonist at CB2 receptors, attenuating the antinociceptive effects of a number of cannabinoids, and as a weak partial agonist at CB1 receptors. It decreases proliferation and...
Keywords: | 6-Iodopravodoline, [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-methanone |
Application: | CB2 receptor antagonist |
CAS | 164178-33-0 |
MW: | 504.4 D |
From 77.00€
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Item number: Cay10006967-10
Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor. It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 µM. Zileuton inhibits leukotriene B4 (LTB4, Cay-20110) production induced by the calcium ionophore A23187 (Cay-11016) in purified human peripheral blood...
Keywords: | A 64077, N-(1-benzo[b]thien-2-ylethyl)-N-hydroxy-urea |
Application: | 5-LO inhibitor |
CAS | 111406-87-2 |
MW: | 236.3 D |
From 28.00€
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Item number: Cay10006972-10
AM281 is a potent and selective central cannabinoid (CB1) receptor antagonist/inverse agonist (Kis = 12 nM and 4,200 nM for CB1 and CB2, respectively). Structurally, it is an analog of the CB1 inverse agonist rimonabant (Cay-9000484). It has no effect on the vanilloid TRPV1 receptor. AM281 has been used to evaluate...
Keywords: | 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide |
Application: | Forensic studies, Difuran analog |
CAS | 202463-68-1 |
MW: | 557.2 D |
From 33.00€
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