Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the large family of nuclear hormone receptors. There are three subtypes, PPARalpha, beta/delta, and gamma, which are expressed at variable levels in different tissues. The Cayman Chemical PPARgamma...

CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 (Cay-12086) that contains an alkyne moiety for use in click chemistry reactions. Its ability to inhibit N-acetyltransferase 10 activity has been used to modulate chromatin organization in order to study changes in nuclear architecture...

9-oxo-10(E),12(E)-Octadecadienoic acid (9-oxo ODA) is a natural agonist, abundant in tomatoes, that activates PPARalpha at 10-20 µM. It is produced from conjugated linoleic acid, which is also known to be a PPARalpha agonist. 9-oxo ODA increases the expression of genes regulated by PPARalpha in primary mouse...

Synonyms: Peroxisome Proliferator-Activated Receptor.

Stearidonic acid (18:4omega-3) is a rare polyunsaturated fatty acid of the omega-3 series. In normal humans, it represents less than 0.25% of serum phospholipid fatty acids. It is present in certain natural oils such as echium and black currant seed, and to the extent that these oils are incorporated into...