15 products were found matching "Cay13285"!

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Cytochalasin B
Cytochalasin B

Item number: Cay11328-5

Cytochalasin B is a cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments. By disrupting actin polymerization, cytochalasin B blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis,...
Keywords: NSC 107658, Phomin,...
Application: Mycotoxin
CAS 14930-96-2
MW: 479.6 D
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Cannabidiol dimethyl ether
Cannabidiol dimethyl ether

Item number: Cay13285-1

Cannabidiol dimethyl ether (Cay-13285) is an analytical reference standard that is structurally similar to known phytocannabinoids. This product is intended for research and forensic applications.Formal Name: 1,3-dimethoxy-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-benzene. CAS Number:...
Keywords: Cannabidiol Dimethyl Ether, Cannabidiol-2',6'-Dimethyl Ether,...
Application: Analytical reference standard, 15-LO inhibitor
CAS 1242-67-7
MW: 342.5 D
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Panobinostat
Panobinostat

Item number: Cay13280-5

Panobinostat is a pan-inhibitor of histone deacetylases (HDACs, Kis = 0.6-31 nM for HDAC1-11). It inhibits growth in a panel of 37 human or mouse lung cancer cell lines, including small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), and mesothelioma cells (IC50s = 4-175, 5-310, and 5-470 nM,...
Keywords: LBH-589, (2E)-N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide
Application: HDAC inhibitor
CAS 404950-80-7
MW: 349.4 D
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MS-275
MS-275

Item number: Cay13284-5

MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 µM). However, it does not inhibit HDAC8 (IC50 > 100 µM). MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in...
Keywords: Entinostat, SNDX 275, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-carbamic acid, 3-pyridinylmethyl ester
Application: HDAC inhibitor
CAS 209783-80-2
MW: 376.4 D
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FK-866
FK-866

Item number: Cay13287-5

FK-866 is a highly specific non-competitive inhibitor of Nampt (Ki = 0.4 nM), causing gradual NAD+ depletion. In HepG2 human liver carcinoma cells, NAD+ depletion by FK-866 directs delayed cell death by apoptosis (IC50 = ~1 nM). In normal human smooth muscle cells, FK-866 causes premature senescence, an effect that...
Keywords: K 22.175, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide
Application: NAMPT inhibitor
CAS 658084-64-1
MW: 391.5 D
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CAY10599
CAY10599

Item number: Cay13282-5

CAY10599 is an agonist of peroxisome proliferator-activated receptor gamma (PPARgamma, EC50 = 0.05 µM in a transactivation assay). It is selective for PPARgamma over PPARalpha and PPARdelta (EC50s = 3.99 and >10 µM, respectively, in transactivation assays).Formal Name:...
Keywords: 2-[[1-[3-[4-([1,1'-biphenyl]-4-ylcarbonyl)-2-propylphenoxy]propyl]-1,2,3,4-tetrahydro-5-quinolinyl]oxy]-2-methyl-propanoic...
Application: PPARgamma agonist
CAS 1143573-33-4
MW: 591.7 D
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CB-86
CB-86

Item number: Cay13289-5

CB-86 is a resorcinol-anandamide hybrid compound that acts as a partial agonist for the central cannabinoid (CB1) receptor and a neutral antagonist for the peripheral cannabinoid (CB2) receptor with Ki values of 5.6 and 7.9 nM, respectively. Its demonstrated potency is similar to that of WIN 55,212-2 (Ki = 21 and...
Keywords: N-cyclopropyl-8-[3-(1,1-dimethylheptyl)-5-hydroxyphenoxy]-octanamide
Application: CB1 receptor partial agonist, CB2 receptor neutral antagonist
CAS 1150586-64-3
MW: 417.6 D
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CAY10598
CAY10598

Item number: Cay13281-5

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10598 is a very potent agonist of EP4, binding with a Ki value of 1.2...
Keywords: 5-[(3S)-3-hydroxy-4-phenyl-1-buten-1-yl]1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone
Application: EP4 agonist
CAS 346673-06-1
MW: 383.5 D
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Itraconazole
Itraconazole

Item number: Cay13288-25

Itraconazole is an antifungal agent and inhibitor of hedgehog signaling (IC50 = 800 nM). It binds to 14-alpha sterol demethylase/CYP51 isoform B (AF51B, Kd = 31 nM for A. fumigatus enzyme expressed in E. coli) and inhibits ergosterol biosynthesis in C. neoformans (IC50 = 6 nM after a 16-hour incubation). It inhibits...
Keywords: 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl...
Application: Hedgehog signaling antagonist
CAS 84625-61-6
MW: 705.6 D
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Bisindolylmaleimide I
Bisindolylmaleimide I

Item number: Cay13298-5

Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine (Cay-81590). It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCalpha,...
Keywords: BIM I, GF 109203X, Gö 6850, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Application: PKC inhibitor
CAS 133052-90-1
MW: 412.5 D
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L-DOPA
L-DOPA

Item number: Cay13248-5

L-DOPA is a metabolic precursor of dopamine that is capable of crossing the blood-brain barrier. It is produced from L-tyrosine by tyrosine hydroxylase and metabolized by catechol-O-methyl transferase (COMT). In the brain L-DOPA is converted to dopamine. Formulations containing L-DOPA have been used in stroke...
Keywords: 3,4-Dihydroxyphenylalanine, Levodopa, 3-hydroxy-L-tyrosine
Application: Neuropharmacological agent
CAS 59-92-7
MW: 197.2 D
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3-Deazaneplanocin A
3-Deazaneplanocin A

Item number: Cay13828-5

3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase. It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells...
Keywords: DZNep, NSC 617989, 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol
Application: S-adenosyl-L-homosysteine hydrolase inhibitor
CAS 102052-95-9
MW: 262.3 D
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