- Search results for Cay13285
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15 products were found matching "Cay13285"!
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Item number: Cay11328-5
Cytochalasin B is a cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments. By disrupting actin polymerization, cytochalasin B blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis,...
Keywords: | NSC 107658, Phomin,... |
Application: | Mycotoxin |
CAS | 14930-96-2 |
MW: | 479.6 D |
From 60.00€
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Item number: Cay13285-1
Cannabidiol dimethyl ether (Cay-13285) is an analytical reference standard that is structurally similar to known phytocannabinoids. This product is intended for research and forensic applications.Formal Name: 1,3-dimethoxy-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-benzene. CAS Number:...
Keywords: | Cannabidiol Dimethyl Ether, Cannabidiol-2',6'-Dimethyl Ether,... |
Application: | Analytical reference standard, 15-LO inhibitor |
CAS | 1242-67-7 |
MW: | 342.5 D |
From 76.00€
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Item number: Cay13280-5
Panobinostat is a pan-inhibitor of histone deacetylases (HDACs, Kis = 0.6-31 nM for HDAC1-11). It inhibits growth in a panel of 37 human or mouse lung cancer cell lines, including small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), and mesothelioma cells (IC50s = 4-175, 5-310, and 5-470 nM,...
Keywords: | LBH-589, (2E)-N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide |
Application: | HDAC inhibitor |
CAS | 404950-80-7 |
MW: | 349.4 D |
From 39.00€
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Item number: Cay13284-5
MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 µM). However, it does not inhibit HDAC8 (IC50 > 100 µM). MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in...
Keywords: | Entinostat, SNDX 275, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-carbamic acid, 3-pyridinylmethyl ester |
Application: | HDAC inhibitor |
CAS | 209783-80-2 |
MW: | 376.4 D |
From 28.00€
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Item number: Cay13287-5
FK-866 is a highly specific non-competitive inhibitor of Nampt (Ki = 0.4 nM), causing gradual NAD+ depletion. In HepG2 human liver carcinoma cells, NAD+ depletion by FK-866 directs delayed cell death by apoptosis (IC50 = ~1 nM). In normal human smooth muscle cells, FK-866 causes premature senescence, an effect that...
Keywords: | K 22.175, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide |
Application: | NAMPT inhibitor |
CAS | 658084-64-1 |
MW: | 391.5 D |
From 35.00€
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Item number: Cay13282-5
CAY10599 is an agonist of peroxisome proliferator-activated receptor gamma (PPARgamma, EC50 = 0.05 µM in a transactivation assay). It is selective for PPARgamma over PPARalpha and PPARdelta (EC50s = 3.99 and >10 µM, respectively, in transactivation assays).Formal Name:...
Keywords: | 2-[[1-[3-[4-([1,1'-biphenyl]-4-ylcarbonyl)-2-propylphenoxy]propyl]-1,2,3,4-tetrahydro-5-quinolinyl]oxy]-2-methyl-propanoic... |
Application: | PPARgamma agonist |
CAS | 1143573-33-4 |
MW: | 591.7 D |
From 60.00€
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Item number: Cay13289-5
CB-86 is a resorcinol-anandamide hybrid compound that acts as a partial agonist for the central cannabinoid (CB1) receptor and a neutral antagonist for the peripheral cannabinoid (CB2) receptor with Ki values of 5.6 and 7.9 nM, respectively. Its demonstrated potency is similar to that of WIN 55,212-2 (Ki = 21 and...
Keywords: | N-cyclopropyl-8-[3-(1,1-dimethylheptyl)-5-hydroxyphenoxy]-octanamide |
Application: | CB1 receptor partial agonist, CB2 receptor neutral antagonist |
CAS | 1150586-64-3 |
MW: | 417.6 D |
From 50.00€
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Item number: Cay13281-5
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10598 is a very potent agonist of EP4, binding with a Ki value of 1.2...
Keywords: | 5-[(3S)-3-hydroxy-4-phenyl-1-buten-1-yl]1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone |
Application: | EP4 agonist |
CAS | 346673-06-1 |
MW: | 383.5 D |
From 129.00€
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Item number: Cay13288-25
Itraconazole is an antifungal agent and inhibitor of hedgehog signaling (IC50 = 800 nM). It binds to 14-alpha sterol demethylase/CYP51 isoform B (AF51B, Kd = 31 nM for A. fumigatus enzyme expressed in E. coli) and inhibits ergosterol biosynthesis in C. neoformans (IC50 = 6 nM after a 16-hour incubation). It inhibits...
Keywords: | 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl... |
Application: | Hedgehog signaling antagonist |
CAS | 84625-61-6 |
MW: | 705.6 D |
From 40.00€
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Item number: Cay13298-5
Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine (Cay-81590). It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCalpha,...
Keywords: | BIM I, GF 109203X, Gö 6850, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
Application: | PKC inhibitor |
CAS | 133052-90-1 |
MW: | 412.5 D |
From 115.00€
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Item number: Cay13248-5
L-DOPA is a metabolic precursor of dopamine that is capable of crossing the blood-brain barrier. It is produced from L-tyrosine by tyrosine hydroxylase and metabolized by catechol-O-methyl transferase (COMT). In the brain L-DOPA is converted to dopamine. Formulations containing L-DOPA have been used in stroke...
Keywords: | 3,4-Dihydroxyphenylalanine, Levodopa, 3-hydroxy-L-tyrosine |
Application: | Neuropharmacological agent |
CAS | 59-92-7 |
MW: | 197.2 D |
From 26.00€
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Item number: Cay13828-5
3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase. It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells...
Keywords: | DZNep, NSC 617989, 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol |
Application: | S-adenosyl-L-homosysteine hydrolase inhibitor |
CAS | 102052-95-9 |
MW: | 262.3 D |
From 130.00€
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