Chemokines are chemotactic cytokines that exert their biological effects by interacting with G protein-linked transmembrane receptors (GPCRs) called chemokine receptors.
Chemokines molecular weight ranges from 8 kDa to 10 kDa and show 20%-50% sequence homology among each other at the protein level. Chemokines share common gene and tertiary structure. Chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
Important Chemokines - Eotaxin (CCL11)
- Eotaxin-2 (CCL24)
- Eotaxin-3 (CCL26)
- GRO (CXCL1, CXCL2, CXCL3)
- Interleukin-8 (CXCL8)
- IP-10 (CXCL10)
- I-TAC (CXCL11)
- Lymphotactin (XCL1)
- MCP (CCL2, CCL7, CCL8, CCL13)
- MDC (CCL22)
- MEC (CCL28)
- MIG (CXCL9)
- MIP (CCL3, CCL4, CCL15, CCL18, CCL19, CCL20, CCL23, CXCL2)
- Platelet Factor-4 (CXCL4)
- Rantes (CCL5)
- SDF (CXCL12)
- TARC (CCL17)
More Chemokines
Chemokine Overview
In the table below the name of chemokines are linked to the appropriate chemokine order information and the name of target receptors are linked to the appropriate antibody order information.
CC chemokines | | Name | Gene | Other name(s) | Receptor | Uniprot | | CCL1 | Scya1 | I-309, TCA-3 | CCR8 | | | CCL2 | Scya2 | MCP-1 | CCR2 | P13500 | | CCL3 | Scya3 | MIP-1a | CCR1 | P10147 | | CCL4 | Scya4 | MIP-1b | CCR1, CCR5 | P13236 | | CCL5 | Scya5 | RANTES | CCR5 | P13501 | | CCL6 | Scya6 | C10, MRP-2 | CCR1 | P27784 | | CCL7 | Scya7 | MARC, MCP-3 | CCR2 | P80098 | | CCL8 | Scya8 | MCP-2 | CCR1, CCR2B, CCR5 | P80075 | | CCL9/CCL10 | Scya9 | MRP-2, CCF18, MIP-1γ | CCR1 | P51670 | | CCL11 | Scya11 | Eotaxin | CCR2, CCR3, CCR5 | P51671 | | CCL12 | Scya12 | MCP-5 | | Q62401 | | CCL13 | Scya13 | MCP-4, NCC-1, Ckβ10 | CCR2, CCR3, CCR5 | Q99616 | | CCL14 | Scya14 | HCC-1, MCIF, Ckβ1, NCC-2, CCL | CCR1 | Q16627 | | CCL15 | Scya15 | Leukotactin-1, MIP-5, HCC-2, NCC-3 | CCR1, CCR3 | Q16663 | | CCL16 | Scya16 | LEC, NCC-4, LMC, Ckβ12 | CCR1, CCR2, CCR5, CCR8 | O15467 | | CCL17 | Scya17 | TARC, dendrokine, ABCD-2 | CCR4 | Q92583 | | CCL18 | Scya18 | PARC, DC-CK1, AMAC-1, Ckβ7, MIP-4 | | P55774 | | CCL19 | Scya19 | ELC, Exodus-3, Ckβ11 | CCR7 | Q99731 | | CCL20 | Scya20 | LARC, Exodus-1, Ckβ4 | CCR6 | P78556 | | CCL21 | Scya21 | SLC, 6Ckine, Exodus-2, Ckβ9, TCA-4 | CCR7 | O00585 | | CCL22 | Scya22 | MDC, DC/β-CK | CCR4 | O00626 | | CCL23 | Scya23 | MPIF-1, Ckβ8, MIP-3, MPIF-1 | CCR1 | P55773 | | CCL24 | Scya24 | Eotaxin-2, MPIF-2, Ckβ6 | CCR3 | O00175 | | CCL25 | Scya25 | TECK, Ckβ15 | CCR9 | O15444 | | CCL26 | Scya26 | Eotaxin-3, MIP-4a, IMAC, TSC-1 | CCR3 | Q9Y258 | | CCL27 | Scya27 | CTACK, ILC, Eskine, PESKY, skinkine | CCR10 | Q9Y4X3 | | CCL28 | Scya28 | MEC | CCR3, CCR10 | Q9NRJ3 | CXC chemokines | | Name | Gene | Other name(s) | Receptor | Uniprot | | CXCL1 | Scyb1 | Gro-α, GRO1, NAP-3, KC | CXCR2 | P09341 | | CXCL2 | Scyb2 | Gro-β, GRO2, MIP-2a | CXCR2 | P19875 | | CXCL3 | Scyb3 | Gro-γ, GRO3, MIP-2b | CXCR2 | P19876 | | CXCL4 | Scyb4 | PF-4 | CXCR3B | P02776 | | CXCL5 | Scyb5 | ENA-78 | CXCR2 | P42830 | | CXCL6 | Scyb6 | GCP-2 | CXCR1, CXCR2 | P80162 | | CXCL7 | Scyb7 | NAP-2, CTAPIII, β-Ta, PEP | | P02775 | | CXCL8 | Scyb8 | IL-8, NAP-1, MDNCF, GCP-1 | CXCR1, CXCR2 | P10145 | | CXCL9 | Scyb9 | MIG, CRG-10 | CXCR3 | Q07325 | | CXCL10 | Scyb10 | IP-10, CRG-2 | CXCR3 | P02778 | | CXCL11 | Scyb11 | I-TAC, β-R1, IP-9 | CXCR3, CXCR7 | O14625 | | CXCL12 | Scyb12 | SDF-1, PBSF | CXCR4, CXCR7 | P48061 | | CXCL13 | Scyb13 | BCA-1, BLC | CXCR5 | O43927 | | CXCL14 | Scyb14 | BRAK, bolekine | | O95715 | | CXCL15 | Scyb15 | Lungkine, WECHE | | Q9WVL7 | | CXCL16 | Scyb16 | SRPSOX | CXCR6 | Q9H2A7 | | CXCL17 | VCC-1 | DMC, VCC-1 | | Q6UXB2 | C chemokines | | Name | Gene | Other name(s) | Receptor | Uniprot | | XCL1 | Scyc1 | Lymphotactin a, SCM-1a, ATAC | XCR1 | P47992 | | XCL2 | Scyc2 | Lymphotactin β, SCM-1β | XCR1 | Q9UBD3 | CX3C chemokines | | Name | Gene | Other name(s) | Receptor | Uniprot | | CX3CL1 | Scyd1 | Fractalkine, Neurotactin, ABCD-3 | CX3CR1 | P78423 |
The Uniprot numbers in this table refer to the human version of the chemokine.
References
http://en.wikipedia.org/wiki/Chemokine
Cytokines
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