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SWI/SNF-like Chromatin-Remodeling Complexes

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The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes.
These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. Two fractions of SWI/SNF-like complexes, SWI/SNF-A (BAF) and SWI/SNF-B (PBAF), have been isolated. The SWI/SNF-A (BAF) complex is defined by the presence of a BAF250/ARID1A subunit and either a SMARCA4/Brg1 or SMARCA2/Brm subunit, while the SWI/SNF-B (PBAF) complex lacks the BAF250/ARID1A subunit and contains a SMARCA4/Brg1 subunit and a polybromo/BAF180 subunit. In addition to these defining subunits, the SWI/SNF-A (BAF) and SWI/SNF-B (PBAF) complexes possess multiple subunits of other SMARCs and/or BAFs that are present in various combinations to provide the mammalian cell with a functional variety of SWI/SNF-like chromatin-remodeling complexes. This growing family of interacting proteins has also been shown to associate with the N-CoR (nuclear receptor co-repressor) deacetylase complex and various nuclear transcription factors. Current information indicates an important role for these complexes in the regulation of cell growth and proliferation. Future studies will likely demonstrate that the SWI/SNF proteins are important to many aspects of development and tumorigenesis.

Bethyl Laboratories current portfolio of antibodies to these proteins, includes, ARID1B, BAF250/ARID1A, BAF53A, SMARCA1/SNF2L, SMARCA2/BRM, SMARCA3, SMARCA4/BRG1, SMARCB1/SNF5, SMARCC1/BAF155, SMARCC2/BAF170, SMARCE1/BAF57, and SNF2h/ISWI.

Product Links


                  Applications 
 Target  Western Blot  IHC  Immunoprecipitation
 ARID1B  A301-046A
 IHC-00234 
 A301-046A
 A301-047A
 BAF53A  A301-391A  IHC-00287  
 BAF250/ARID1A    A301-040A
 A301-041A
  
 
 SMARCA1/SNF2L  A301-086A  IHC-00230  A301-086A
 SMARCA2/BRM  A301-014A
 A301-015A
 A301-016A
   A301-014A
 A301-015A
 A301-016A
 SMARCA3  A300-229A
 A300-230A
   
 A300-230A
 SMARCA4/BRG1  A300-813A    A300-813A
 SMARCAD1  
 A301-593A
   A301-592A
 A301-593A
 SMARCB1/SNF5  A301-087A  IHC-00228  A301-087A
 SMARCC1/BAF155  A301-019A
 A301-020A
 A301-021A
   A301-019A
 A301-020A
 A301-021A
 SMARCC2/BAF170  A301-038A
 A301-039A
 IHC-00213
 A301-038A
 A301-039A
 SMARCD1/BAF60a   
 A301-595A
   A301-594A
 SMARCE1/BAF57  A300-810A    A300-810A
 SNF2h/ISWI  A301-017A
   A301-017A
 A301-018A


See also: Chromatin-remodeling Complexes: Antibodies to CHD Proteins


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