Kontakt 0800-2466651 DE | EN Merkliste Login Warenkorb
Reset
Suche
zurück

Hersteller INFO

RNA Processing: Antibodies and Peptides (A-N)

Info

Bethyl Laboratories produces many antibodies for detection of proteins involved in RNA processing.

In this alphabetical listing headings are hyperlinked to product order information with price and corresponding datasheets:


AKAP1

AKAP1 (A-kinase anchor protein 1) was isolated as a protein that interacts with the regulatory subunit of protein kinase A (PKA) as well as the catalytic subunit of protein phosphatase 1 (PPI). AKAP1 plays a role in directing the subcellular localization of PKA to the cytoplasmic face of the outer mitochondrial membrane. Alternate names for AKAP1 include A-kinase anchor protein 1 mitochondrial, protein kinase A-anchoring protein 1, PRKA, A-kinase anchor protein 149 kDa, AKAP149, dual specificity A-kinase-anchoring protein 1, D-AKAP-1, spermatid a-kinase anchor protein 84, S-AKAP84, AKAP149, AKAP84, SAKAP84, and MGC1807.

ATXN2L


Ataxin 2-like (ATXN2L) is related to the spinocerebellar ataxia (SCA) family of proteins associated with a group of neurodegenerative disorders characterized by progressive ataxia and cerebellar dysfunction. The specific function of ATXN2L has not been described.

BARD1


BRCA1 associated RING domain 1 (BARD1) together with BRCA1 is an E3 ubiquitin ligase. BARD1/BRCA1 has been shown to ubiquinate RNA polymerase II in response to DNA damage. BARD1/BRCA1 ubiquitin ligase activity has also been shown to be important in the prevention of double stranded breaks and the regulation of centrosome number.

BCAS2


Breast cancer amplified sequence 2 (BCAS2) was identified as a gene overexpressed and amplified in breast cancer cell lines and primary breast cancer tissues. BCAS2 has also been identified as a component of the splicesome and as a protein that interacts with the estrogen receptor and potentiates its function. Alternate designations of BCAS2 include DNA amplified in mammary carcinoma 1 protein, splicesome-associated protein SPF27, and DAM1.

CA150


CA150 has been identified as a transcriptional cofactor that functions as a corepressor of Tat-activated and C/EBP-activated gene transcription. CA150 also has been shown to interact with RNA polymerase II and the splicing factor SF1 to function in transcription elongation and pre-mRNA splicing. Alternate names for CA150 include transcription elongation regulator 1, TATA box-binding protein-associated factor 2S, transcription factor CA150, TCERG1, TAF2S, and MGC133200.

Caper


Caper, also known as RBM39 (RNA-binding motif protein 39) contains an RNA recognition motif found in a variety of RNA binding proteins that function in RNA processing. In the nucleus, caper associates with splicesomal machinery and also functions as a coactivator of the estrogen receptor and JUN/AP1. Alternate designations for caper include RNA-binding region-containing 2, hepatocellular carcinoma protein 1, splicing factor HCC1, HCC1, RNPC2, FLJ44170, CAPERalpha, and DKFZp781C0423.

CPSF59

CPSF59 is the the 59 kDa subunit of the cleavage factor Im complex (CFIm). The CFIm is a heterodimer composed of a 25 kDa (CPSF5) subunit and either the 59 kDa (CPSF7) or 68 kDa (CPSF6) subunit and is essential to the first step of pre-mRNA 3’-end processing. CPSF59 bears an RNA-recognition motif (RRM). Alternate names for CPSF59 include CPSF7, cleavage and polyadenylation specific factor 7, cleavage and polyadenylation specificity factor 59 kDa subunit, CPSF 59 kDa subunit, pre-mRNA cleavage factor Im 59 kDa subunit, FLJ125296, and MGC9315.

CPSF68


Cleavage and polyadenylation specific factor 68 (CPSF68) is the 68 kDa subunit of the cleavage factor Im complex (CFIm). The CFIm is a heterodimer composed of a 25 kDa (CPSF5) subunit and either the 59 kDa (CPSF7) or 68 kDa (CPSF6) subunit and is essential to the first step of pre-mRNA 3’-end processing. CPSF68 bears an N-terminal RNA- recognition motif (RRM) that is necessary for binding CPS5. Alternate names for CPSF68 include CPSF6, cleavage and polyadenylation specificity factor 68 kDa subunit, CPSF 68 kDa subunit, pre-mRNA cleavage factor Im 68 kDa subunit, HPBRII-4/7, and CFIM68.

CPSF73


CPSF73 is the 73 kDa subunit of the cleavage and polyadenylation specificity factor (CPSF) complex that functions in pre-mRNA-3’-end formation. CPSF73 has been implicated as the endonuclease component of the CPSF complex for pre-mRNA-3’ end processing. CPSF73 is also known as cleavage and polyadenylation specificity factor subunit 3, cleavage and polyadenylation specificity factor 73 kDa subunit, CPSF 73 kDa subunit, and CPSF-73.

CRM1


Chromosome region maintenance 1 protein homolog (CRM1) is the Ran-GTP-binding nuclear export receptor for proteins bearing a leucine rich nuclear export signal and RNAs. CRM1 also possesses a mitotic function as it localizes to kinetochores, and with Ran-GTP, recruits Ran-GTPase-activating protein (Ran-GAP1) and Ran-binding protein (Ran-BP2) for proper mitotic spindle assembly and chromosome segregation. Additionally, CRM1 is suggested to function as a loading dock of various cell cycle and checkpoint factors such as cyclins, Cdks, p53 and BRCA1, to regulate proper chromosome duplication and genomic stability. CRM1 is also known as exportin-1, Exp1, XPO1, and DKFZp686B1823.

CSTF50


CSTF50 is one of three subunits that comprise the cleavage stimulation factor (CSTF) complex. CSTF is part of the polyadenylation machinery that adds adenylate residues to the 3’-ends of eukaryotic pre-mRNAs. In the CSTF complex, CSTF50 interacts with CSTF77 (CSTF3), and CSTF64 (CSTF2). CSTF50 is also known as cleavage stimulation factor 50 kDa subunit, CSTF 50 kDa subunit, CF-1 50 kDa subunit, CstF-50, and CSTF1.

CSTF64


CSTF64 is the RNA-binding 64 kDa subunit of the cleavage stimulation factor (CstF). CstF is part of the polyadenylation machinery that adds adenylate residues to the 3’-ends of eukaryotic pre-mRNAs. In the CstF complex, CSTF64 interacts with CSTF1 (CSTF50), and CSTF3 (CSTF77). CSTF is also known as cleavage stimulation factor 64 kDa subunit, CSTF 64 kDa subunit, CF-1 64 kDa subunit, CstF-64, and CSTF2.


CSTF77


CSTF77 is one of three subunits that comprise the cleavage stimulation factor (CstF) complex. CstF is part of the polyadenylation machinery that adds adenylate residues to the 3’-ends of eukaryotic pre-mRNAs. In the CstF complex, CSTF77 interacts with CSTF1 (CSTF50), and CSTF2 (CSTF64). CSTF77 is also known as cleavage stimulation factor 77 kDa subunit, CSTF 77 kDa subunit, CF-1 77 kDa subunit, CstF-77, CSTF3, MGC43001, MGC75122, and MGC117398.

DDX1




DDX10

DDX10 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX10 may play a particular role in ribosome assembly. DDX10 has been observed to be involved in a chromosomal translocation and fused with the nucleoporin gene, NUP98, in myeloid malignancies. Alternate names for DDX10 include probable ATP-dependent RNA helicase DDX10, DEAD box protein 10, and HRH-J8.

DDX17


DDX17 is a member of the DEAD box family of proteins that possesses
several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. Some members of the DEAD box proteins also exhibit functions involved in transcriptional regulation. In addition to a role involved in RNA splicing, DDX17 has been observed to interact with and act as a transcriptional coactivator for estrogen receptor alpha (ERalpha). DDX17 is closely related to and forms heterodimers with DDX5. DDX17 is also known as probable ATP-dependent RNA helicase DDX17, DEAD box protein 17, RNA-dependent helicase p72, DEAD box protein p72, P72, RH70, and DKFZp761H2016.

DDX18


DDX18 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX18 has been observed to be a target of myc-max heterodimers. Alternate names for DDX18 include ATP-dependent RNA helicase DDX18, DEAD box protein 18, myc-regulated DEAD box protein, and MrDb.

DDX19


DDX19 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX19 may be involved in mRNA transport.

DDX21


DDX21 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. Some members of the DEAD box proteins also exhibit functions involved in transcriptional regulation. DDX21 has been shown to be required for the processing of 20S rRNA to 18S and has also been shown to be important for c-Jun transcriptional activation. Alternate names for DDX21 include nucleolar RNA helicase 2, nucleolar RNA helicase II, nucleolar RNA helicase Gu, RH II/Gu, Gu-alpha, DEAD box protein 21, GUA, GURDB, RH-II/GU, RH-II/GuA, and DKFZp686F21172.

DDX23


DDX23 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX23 is a component of the U5 snRNP that may facilitate conformational changes in the splicesome during pre-mRNA splicing. DDX23 is also known as probable ATP-dependent RNA helicase DDX23, DEAD box protein 23, 100 kDa U5 snRNP-specific protein, U5-100kD, PRP28 homolog, PRPF28, and MGC8416.

DDX24


DDX24 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. The specific function of DDX24 has not been elucidated. Alternate names for DDX24 include ATP-dependent RNA helicase DDX24, and DEAD box protein 24.

DDX28


DDX28 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX28 is nuclear shuttling protein and has been found to be localized to the nucleus and mitochondria. DDX28 is also known as probable ATP-dependent RNA helicase DDX28, mitochondrial DEAD box protein 28, and MDDX28.

DDX3


DDX3 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX3 exhibits a variety of functions. DDX3 is a candidate tumor suppressor that suppresses tumor growth and transcriptionally activates the p21 promoter. DDX3 has been shown to play a role in translation as an eIF4E inhibitory protein that regulates translation initiation. These findings, as well as the observation that DDX3 is regulated by hepatitis C virus and is down-regulated in hepatocellular carcinoma, suggest an important role for DDX3 in growth-regulatory functions. DDX3 is also known as ATP-dependent RNA helicase DDX3X, DEAD box protein 3 X-chromosomal, helicase-like protein 2, HLP2, DEAD box X isoform, DDX3X, DBX, and DDX14.

DDX31


DDX31 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes.The function of DDX31 has not been determined. Alternate names for DDX31 include probable ATP-dependent RNA helicase DDX31, DEAD box protein 31, helicain, helicain A, helicain B, helicain C, FLJ13633, FLJ14578, and FLJ23349.

DDX41


DDX41 is a member of the DEAD box family of proteins that possesses
several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. The function of DDX41 has not been determined. Alternate names for DDX31 include probable ATP-dependent RNA helicase DDX41, DEAD box protein 41, DEAD box protein abstrakt homolog, ABS, and MGC8828.

DDX46


DDX46 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX46 is a component of the 17S U2 snRNP complex and plays and important role in pre-mRNA splicing. Alternate names for DDX31 include probable ATP-dependent RNA helicase DDX46, DEAD box protein 46, PRP5 homolog, KIAA0801, MGC9936, and FLJ25329.

DDX51


DDX51 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX51 may function in biogenesis of the 60S ribosomal subunit. Alternate names for DDX51 include ATP-dependent RNA helicase DDX51, DEAD box protein 51, MGC42193, and DKFZp686N2081.

DDX54


DDX54 is a member of the DEAD box family of proteins that possesses
several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX54 has been shown to interact with nuclear hormone receptors in a hormone –dependent manner and repress their transcriptional activity. Alternate names for DDX54 include ATP-dependent RNA helicase DDX54, DEAD box protein 54, ATP-dependent RNA helicase DP97, DP97, and MGC2835.


DDX6


DDX6 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX6 has been observed to positively regulate growth by modulating gene expression at the translational level. Alternate names for DDX6 include probable ATP-dependent RNA helicase DDX6, DEAD box protein 6, ATP-dependent RNA helicase p54, RCK, HLR2, P54, and FLJ36338.

DHX15


DHX15 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DHX15 is the human ortholog of the yeast Prp43 protein. DHX15 has been demonstrated to function in ribosome biogenesis and pre-mRNA splicing. Alternate names for DHX15 include putative pre-mRNA splicing factor ATP-dependent RNA helicase DHX15, DEAH box protein 15, ATP-dependent RNA helicase #46, DBP1, HRH2, PRP43, PRPF43, PrPp43p, and DDX15.

DHX29


DHX29 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH
(Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. The specific function of DHX29 has not been determined. Alternate names for DHX20 include putative ATP-dependent RNA helicase DHX29, DEAH box protein 29, nucleic acid helicase DDXx, and DDX29.


DHX33


DHX33 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. The specific function of DHX33 has not been determined. Alternate names for DHX33 include putative ATP-dependent RNA helicase DHX33, DEAH box protein 33, DDX33, FLJ21972, and DKFZp762F2011.

DHX36


DHX36 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DHX36 expression is highest in testis and plays a role in 3’-5’ degradation of AU-rich RNAs. Interestingly, DHX36 has also been observed to function as a G4-DNA resolvase. In this capacity DHX36 catalyzes the resolution of highly stable G4- DNA structures that form in guanine-rich regions of single-stranded DNA. Alternate names for DHX36 include probable ATP-dependent RNA helicase DHX36, DEAH box protein 36, MLE-like protein 1, RNA helicase associated with AU-rich element ARE, DDX36, KIAA1488, MLEL1, and RHAU.

DHX37


DHX37 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. The specific function of DHX37 has not been determined. Alternate names for DHX33 include putative ATP-dependent RNA helicase DHX37, DEAH box protein 37, DDX37, KIAA1517, MGC2695, MGC4322, MGC46245, and FLJ41974.

DHX38


DHX38 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DHX38 is the human ortholog of the yeast Prp16 protein. DHX38 has been shown to be required for catalytic step II of pre-mRNA splicing. Alternate names for DHX38 include pre-mRNA splicing factor ATP-dependent RNA helicase PRP16, ATP-dependent RNA helicase DHX38, DEAH box protein 38, DDX38, KIAA0224, PRP16, and PRPF16.

DHX8


DHX8 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DHX8 is the human ortholog of the yeast Prp22 protein. DHX8 has been demonstrated to function in the release of RNA from the splicesome and the nuclear export of spliced mRNA. Alternate names for DHX8 include ATP-dependent RNA helicase DHX8, DEAH box protein 8, RNA helicase HRH1, DDX8, HRH1, PRP22, and PRPF22.

DHX9


DHX9 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. Some members of the DEAH box proteins also exhibit functions involved in transcriptional regulation. DHX9 has been shown to act as a bridge between CREB-binding protein (CBP) and RNA polymerase II to coactivate CBP-dependent transcription. A similar observation has been reported for an interaction with BRCA1. DHX9 also exhibits activities associated with nuclear export of retroviral RNAs, translation, RNA editing, and snRNP assembly. Alternate names for DHX9 include ATP-dependent RNA helicase A, RHA, Nuclear DNA helicase II, NDH II, DEAH box protein 9, DDX9, LKP, NDH2, and NDHII.

DICE1/DDX26


DICE1/DDX26 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DICE1/DDX26 is a subunit of the integrator complex involved in 3’-end processing of snRNAs. DICE1/DDX26 is implicated as a tumor suppressor, and its ectopic expression has been shown to inhibit tumor cell growth. Alternate names for DICE1/DDX26 include integrator complex subunit 6, Int6, protein deleted in cancer 1, protein DDX26, DBI-1, deleted in cancer 1, INTS6, DDX26A, HDB, Nochl2, and DKFZP434B105.

DKFZP434B168


DKFZP434B168 is subunit 7 of the integrator complex (INTS7). The integrator complex is composed of at least 12 subunits and associates with the C-terminal domain of RNA polymerase II to mediate 3’-end processing of small-nuclear RNAs (snRNAs). Alternate names for DKFZP434B include integrator complex subunit 7, Int7, INTS7, and C1orf73.

E1B-AP5


E1B-AP5 was identified as a protein that interacts with adenovirus type 5 (Ad5) early 55-kDa oncoprotein. EIB-AP5 is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family that can bind RNA and appears to play a role in mRNA processing and transport. Alternate names E1B-AP5 include heterogeneous nuclear ribonucleoprotein U-like protein 1, adenovirus early region 1B-associated protein 5, E1B-55 kDa-associated protein 5, HNRPUL1, E1BAP5, and FLJ12944.

EWS


EWS is a member of a family of RNA-binding proteins that may serve as adapters that bridge RNA polymerase II complex and RNA splicing factors. Translocations and fusions between EWS and the ETS transcription factors promote oncogenesis and are associated with Ewing’s family tumors. Alternate names for EWS include RNA-binding protein EWS, Ewing sarcoma breakpoint region 1 protein, EWS oncogene, and EWSR1.

FLJ21919


FLJ21919 is also known as INTS3 and has been identified as a component of the twelve-subunit integrator complex that functions in RNA Pol II mediated 3’-end mRNA processing of the U1 and U2 small nuclear RNAs (snRNAs). Alternate names for FLJ21919 include integrator complex subunit 3, int3, C1orf60, C1orf193, DKFZp686E1950, DKFZp781I1253, RP11-216N14.2, and DKFZp686O20115.

FUS


FUS has been identified as a frequent translocation fusion partner of various transcription factors. FUS fusion genes have been shown to be associated with multiple tumor types which include liposarcoma, leukemia, histocytoma, and sarcoma. FUS is a multifunctional RNA-binding protein that associates with the nuclear matrix and Cajal bodies and appears to play a role in splicesome assembly, pre-mRNA splicing, DNA repair, transcriptional regulation and homologous recombination. Alternate names for FUS include RNA-binding protein FUS, oncogene FUS, oncogene TLS, translocated in liposarcomas, TLS, 75 kDa DNA-pairing protein, POMp75, CHOP, FUS-CHOP, TLS/CHOP, and hnRNP-P2.

Gemin4

Gemin4 is a component of the SMN (survival of motor neurons) complex and also localizes to nuclear focal structures called gems or Gemini of coiled bodies. In the SMN complex Gemin4 interacts with the gemin3 DEAD box protein and several core components of the splicesome that mediates pre-mRNA splicing. Alternate names for Gemin4 include component of gems 4, gemin-4, p97, GEMIN4, HC56, HCAP1, HHRF-1, DKFZP434B131, and
DKFZP434D174.

Gemin5


Gemin5 is a component of the SMN (survival of motor neurons) complex. The SMN complex is composed of the SMN protein and several Gemins (2-7) and is involved in the assembly of snRNPs in the cytoplasm and their transport to the nucleus. The SMN complex localizes to nuclear focal structures called gems or Gemini of coiled bodies. Gemin 5 has been shown to be responsible for recognizing and binding the snRNP code during snRNP biogenesis. Recent studies have shown that Gemin 5 is rarely detectable in SMN complexes associated with gems/Cajal bodies in the nucleus and may play a specific role in cytoplasmic SMN complexes. It has also been shown to function as a scaffold protein for ASK1-JNK1 signaling. Alternate names for Gemin5 include Gem-associated protein 5.

HA95/AKAP8L


AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington’s disease. Alternate names for AKAP8L/HA95 include A-kinase anchor protein 8-like, AKAP8-like protein, neighbor of AKAP95, NAKAP95, NAKAP, helicase A-binding protein 95, HAP95, homologous to ADAP95 protein, and HA95.

hnRNP-H


Heterogeneous nuclear ribonucleoprotein H (hnRNP-H) belongs to a group of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind and complex with heterogeneous nuclear RNA (hnRNA) and play a role in pre-mRNA processing and transport. hnRNP-H binds specific cis-sequence elements on pre-mRNA and functions as an accessory factor for splicing by influencing small nuclear ribonucleoprotein (snRNP) binding. Alternate names for hnRNP-H include HNRPH, HNRPH1, and DKFZp686A15170.

hnRNP-K


Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) belongs to a group of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind and complex with heterogeneous nuclear RNA (hnRNA) and play a role in pre-mRNA processing and transport. hnRNP-K is a multifunctional protein implicated in chromatin remodeling, transcriptional control, translational control and RNA splicing. hnRNP-K has been found to function as a scaffolding protein that facilitates interaction between signaling kinases such as c-Src and factors that mediate mRNA-directed processes. Alternate names for hnRNP-K include transformation up-regulated nuclear protein, TUNP, HNRPK, HNRNPK, CSBP, TUNP, HNRNPK, and FLJ41122.

hnRNP-U


Heterogeneous nuclear ribonucleoprotein U (hnRNP-U) belongs to a group of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind and complex with heterogeneous nuclear RNA (hnRNA) and play a role in pre-mRNA processing and transport. In addition to its RNA-binding domain, hnRNP-U contains a scaffold-associated region (SAR)-specific bipartite DNA-binding domain. Recent evidence suggests that hnRNP-U influences the expression of several genes by regulating mRNA stability. Alternate names for hnRNP-U include scaffold attachment factor A, SAF-A, p120, pp120, HNRPU, SAFA, and U21.1.

INT11


INT11 has been identified as a component of the twelve-subunit integrator complex that functions in RNA Pol II mediated 3’-end mRNA processing of the U1 and U2 small nuclear RNAs (snRNAs). INT11 is a beta-lactamase family member that has sequence similarity to the cleavage and polyadenylation specificity factors CPSF-73 and CPSF-100. Alternate names for INT11 include integrator complex subunit 11, cleavage and polyadenylation-specific factor 3-like protein, CPSF3-like protein, protein related to CPSF subunits of 68kDa, RC-68, CPSF73L, INTS11, FLJ13294, and FLJ20542.

INT4


INT4 has been identified as a component of the twelve-subunit integrator complex that functions in RNA Pol II mediated 3’-end mRNA processing of the U1 and U2 small nuclear RNAs (snRNAs). Alternate names for INT4 include integrator complex subunit 4, INTS4, and MSTP093.

INT5


INT5 has been identified as a component of the twelve-subunit integrator complex that functions in RNA Pol II mediated 3’-end mRNA processing of the U1 and U2 small nuclear RNAs (snRNAs). Alternate names for INT5 include INTS5, and KIAA1698.

INTS9


INTS9 is a beta-lactamase family member that has sequence similarity to the cleavage and polyadenylation specificity factors CPSF-73 and CPSF-100. INTS9 has been identified as a component of the twelve-subunit integrator complex that functions in RNA Pol II mediated 3’-end mRNA processing of the U1 and U2 small nuclear RNAs (snRNAs). INTS9 is also known as integrator complex subunit 9, Int9, protein related to CPSF subunits of 74 kDa, INTS9, RC-74, RC74, and FLJ10871.

KAONASHI/FLJ20530


FLJ20530/KAONASHI1 is also known as INTS8 and has been identified as a component of the twelve-subunit integrator complex that functions in RNA Pol II mediated 3’-end mRNA processing of the U1 and U2 small nuclear RNAs (snRNAs). Alternate names for FLJ20530/KAONASHI1 include integrator complex subunit 8, Int8, kaonashi protein 1, kaonashi-1, C8orf52, FLJ20530, and GC131633.

KARS


KARS is an aminoacyl-tRNA synthetase that functions to charge tRNAs with their cognate amino acids. Alternate names for KARS include lysyl-tRNA synthetase, lysine-tRNA ligase, lysRS, KARS2, and KIAA0070.

KIAA1440


KIAA1440 was first identified as a hypothetical protein predicted from the in silico analysis of long cDNAs isolated in the Kazusa cDNA sequencing project. Targeted disruption of KIAA1440 results in growth arrest at the early blastocyst stage, activated caspase-3/7 that results in apoptosis, and impaired processing of U2 snRNA. KIAA1440 has been demonstrated to be the largest subunit of the integrator complex which functions to mediate U1 and U2 snRNA 3’end processing. Thus, KIAA1440 is also called integrator complex subunit 1 (INTS1).

Matrin 3


Matrin 3 is a nuclear matrix protein that has been observed to mediate multiple cellular processes. Matrin 3 can function to withhold defective RNAs within the nucleus by anchoring them to the nuclear matrix and modulate the promoter activity of genes proximal to matrix/scaffold attachment region (MAR/SAR). Matrin 3 has also been demonstrated to be the main PKA substrate following NMDA receptor activation in NMDA-induced neuronal cell death. Alternate names for Matrin 3 include MATR3, MGC9105, KIAA0723, DKFZp686K0542, and DKFZp686K23100.

NONO


Non-POU-domain-containing octamer binding protein (NONO) is a member of the DBHS (drosophila behavior, human splicing) domain-containing family and is an RNA- and DNA- binding protein. NONO and other DBHS domain-containing proteins are multifunctional and are reported to be involved in transcriptional regulation, mRNA processing, and DNA non-homologous end joining (NHEJ). NONO functions as a coregulator of the androgen receptor (AR) and also regulates cAMP transcriptional activity by interacting with gene promoter elements. NONO is also involved in pre-mRNA splicing through an interaction with U5 snRNA and can stimulate DNA nonhomologous end joining (NHEJ) through the interaction with ku70/G22p and ku80/XRCC5 dimers. Alternate names for NONO include 54 kDa nuclear RNA- and DNA-binding protein, p54 (nrb), 55 kDa nuclear protein, NMT55, DNA-binding p52/p100 complex, NRB54, P54, and P54NRB.

Nucleolin (NCL)


Nucleolin (NCL) is a major nucleolar phosphoprotein that is involved in pre-RNA transcription and the synthesis and maturation of ribosomes. NCL can bind to histone H1 to induce chromatin condensation and may play an additional role in transcriptional elongation. Alternate names for NCL include protein C23 and FLJ45706.

RNA Processing Product Listing continued (P-Z)

zurück Hoch


Forschungsprodukte im Fokus

 

Produkte

Service

Company

€ 10 Gutschein sichern