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AZD 5991
AZD 5991

Item number: Cay28926-1

AZD 5991 is an inhibitor of myeloid cell leukemia-1 (Mcl-1, IC50 = 0.72 nM). It is selective for Mcl-1 over Bcl-2, Bcl-xL, Bcl-W, and Bfl-1 (IC50s = 20, 36, 49, and 24 µM, respectively). AZD 5991 decreases the viability of MV4-11 acute myeloid leukemia (AML) and MOLP-8 multiple myeloma (MM) cells with EC50 values of...
Keywords: (3aR)-5-chloro-2,11,12,24,27,29-hexahydro-2,3,24,33-tetramethyl-22H-9,4,8-(metheniminomethyno)-14,20:26,23-dimetheno-10H,2...
Application: Mcl-1 inhibitor
CAS 2143061-81-6
MW: 672.3 D
From 130.00€ *
Review
Anti-MYSM1
Anti-MYSM1

Item number: E-AB-15991.120

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the...
Keywords: Anti-MYSM1, Anti-2A-DUB, Anti-KIAA1915, EC=3.4.19.-, Anti-Histone H2A deubiquitinase MYSM1, Anti-Myb-like, SWIRM and MPN...
Application: WB, IHC, ELISA
Host: Rabbit
Species reactivity: human, mouse
From 71.00€ *
Review
Dibutyryl-Cyclic GMP (sodium salt)
Dibutyryl-Cyclic GMP (sodium salt)

Item number: Cay15991-50

Dibutyryl-cyclic GMP (dibutyryl-cGMP) is a cell-permeable, cGMP analog that activates cGMP-dependent protein kinase. It has been used in a wide variety of research applications to mimic cGMP interactions and effects on different biological molecules.Formal Name: N-(1-oxobutyl)-cyclic 3',5'-(hydrogen phosphate)...
Keywords: Dibutyryl Guanosine 3',5'-cyclic monophosphate, Dibutyryl-cGMP, N-(1-oxobutyl)-cyclic 3',5'-(hydrogen phosphate)...
Application: Cell-permeable cGMP analog, cGMP-dependent protein kinase activator
CAS 51116-00-8
MW: 507.4 D
From 90.00€ *
Review
DBO-83
DBO-83

Item number: Cay25991-1

DBO-83 is an agonist of nicotinic acetylcholine receptors (nAChRs) with antinociceptive and anti-amnesic activities. It binds to nAChRs in rat cortical membranes with a Ki value of 4.1 nM in a radioligand binding assay with the alpha4beta2 nAChR partial agonist and alpha7 nAChR agonist [3H]cytisine. DBO-83...
Keywords: 3-(6-chloro-3-pyridazinyl)-3,8-diazabicyclo[3.2.1]octane, dihydrochloride
Application: nAChR agonist
CAS 195211-53-1
MW: 297.6 D
From 50.00€ *
Review
MYL4, Human myosin, light chain 4, alkali, atrial, embryonic, Real Time PCR Primer Set
MYL4, Human myosin, light chain 4, alkali, atrial,...

Item number: VHPS-5991

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
Keywords: MYL4, MLC1, PRO1957, Myosin light chain 4, Myosin light chain alkali GT-1 isoform, Myosin light chain 1, embryonic...
Application: RNA quantification
43.00€ *
Review
Srd5A2, Rat steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogen
Srd5A2, Rat steroid-5-alpha-reductase, alpha polypeptide...

Item number: VRPS-5991

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
Keywords: S5AR 2, Srd5a2, SR type 2, EC=1.3.99.5, 5 alpha-SR2, Steroid 5-alpha-reductase 2, 3-oxo-5-alpha-steroid 4-dehydrogenase 2
Application: RNA quantification
52.00€ *
Review
-10 %
Discount Promotion
Anti-phospho-KV2.1 (Ser805)
Anti-phospho-KV2.1 (Ser805)

Item number: ELK-ES5991.100

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth...
Keywords: Anti-phospho-DRK1, Anti-phospho-h-DRK1, Anti-phospho-Delayed rectifier potassium channel 1, Anti-phospho-Voltage-gated...
Application: WB, ELISA, IHC
Host: Rabbit
Species reactivity: human, mouse, rat
169.00€ * From 152.10€ *
Review
Anti-SNW1 (SKIP, SNW Domain-containing Protein 1, Nuclear Protein SkiP, Nuclear Receptor Coactivator
Anti-SNW1 (SKIP, SNW Domain-containing Protein 1, Nuclear...

Item number: 145991.100

TGF-beta and the bone morphogenic proteins (BMPs) are key signaling proteins that regulate numerous cellular processes such as embryonic development and tumorigenesis. Both signal through the Smad protein family and are negatively regulated by Ski and SnoN, two related proto-oncoproteins. Ski functions by binding to...
Application: ELISA, IF, WB
Host: Rabbit
Species reactivity: human, mouse, rat
644.00€ *
Review
Anti-CBFA2T2
Anti-CBFA2T2

Item number: E-AB-52991.120

In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is...
Keywords: Anti-EHT, Anti-p85, Anti-CBFA2T2, Anti-Protein CBFA2T2, Anti-MTG8-like protein, Anti-MTG8-related protein 1, Anti-ETO...
Application: IHC, ELISA
Host: Rabbit
Species reactivity: human, mouse
From 71.00€ *
Review
Myosin Light Chain 1, Alkali, Fast Skeletal (MYL1) Recombinant, Human
Myosin Light Chain 1, Alkali, Fast Skeletal (MYL1)...

Item number: 155991.10

Accession Number: P05976/
From 399.00€ *
Review