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Antibodies against Proteins in the Circadian Pathway


On many levels circadian rhythm is central to animal physiology.
Based on the daily 24-hour solar cycle and extending to axis-tilt and seasons, the circadian clock functions as an intrinsic time-keeper that coordinates the function of the major organs of the body. At the top of the hierarchy for circadian control lies the superchiasmatic nucleus (SCN) of the anterior hypothalamus. The SCN receives light signals via the retinohypothalamic tract (RHT) and functions as the master oscillator. As the master, the SCN synchronizes and coordinates slave oscillators located in other parts of the brain as well as in the peripheral organs. At the cellular level, the SCN is implicated to house distinct populations of neurons that hold the molecular machinery required for the function of the master clock. At the molecular level, the clock machinery consists of a group of transcription factors that function under positive and negative feedback loops and regulate gene expression via specific regulatory elements. Central to these feedback loops are the period (Per1, Per2, and Per3) and cryptochrome (Cry1 and Cry2) genes whose transcription is regulated by the CLOCK/BMAL1 heterodimeric transcription factor. Since this group of clock genes also has been found to be expressed with periodicity in tissues and organs peripheral to the SCN, there is a need to understand how the master and slave oscillators interact. Additionally, since the circadian rhythm has been linked to human health, it will be important to find specifically how these genes play a role in the development of disease.

Selected Review

1. M. Hastings, J. S. ONeill, and E. S. Maywood, "Circadian Clocks: Regulators of Endocrine and Metabolic Rhythms," J Endocrinol. 195, no. 2 (2007): 187-198.
2. S. M. Reppert and D. R. Weaver, "Coordination of Circadian Timing in Mammals," Nature. 418, no. 6901 (2002): 935-941.

Bethyl Laboratories Portfolio of Antibodies against Proteins in the Circadian Pathway

BMAL1 Antibodies
CK1 delta Antibodies
CLOCK Antibodies
CREB Antibodies
Cry1 Antibodies
Cry2 Antibodies
DEC1 Antibodies
EAR2 Antibodies
EGFR Antibodies
PHLPP Antibodies
Timeless Antibodies

More Antibodies to Proteins involved in Biological Rhythms

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