Histone methylation is a reversible posttranslational modification.
It modulates chromatin structure for the regulation of transcriptional and cellular epigenetic status. The modification of histones is critical to the developmental process, and accumulating evidence suggests that aberrant regulation of histone methylation is involved in tumorigenesis (1). The dynamic process of histone methylation occurs on histone lysine and arginine residues. The demethylation of histone lysines is catalyzed by at least two protein families:
1. T. Takeuchi et al., "Roles of Jumonji and Jumonji Family Genes in Chromatin Regulation and Development," Dev.Dyn. 235, no. 9 (2006): 2449-2459.
2. X. Tian and J. Fang, "Current Perspectives on Histone Demethylases," Acta Biochim.Biophys.Sin.(Shanghai). 39, no. 2 (2007): 81-88.
Bethyl Laboratories Portfolio of Antibodies to Jumonji Proteins
LSD1 Antibodies ...