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Growth Differentiation Factor 5, His Tag, human recombinant (rHuGDF5-His)
Product information "Growth Differentiation Factor 5, His Tag, human recombinant (rHuGDF5-His)"
Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. (www.uniprot.org) Human recombinant GDF5 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 141 amino acids (fragment 382-501) and having a total molecular mass of 15.8 kDa. GDF5 is fused to 20 amino acid His Tag at N-terminus. GDF-5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia (Hunter-Thompson type), brachydactyly (type C) and chondrodysplasia (Grebe type). These associations confirm that the gene product plays a role in skeletal development.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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