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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A301-284A-T | 10 µl (2 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A301-284A | 100 µl | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in... more
Product information "Anti-NBS1"
Protein function: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex. [The UniProt Consortium]
Keywords: | Anti-Nbn, Anti-Nbs1, Anti-Nibrin, Anti-Cell cycle regulatory protein p95, Anti-Nijmegen breakage syndrome protein 1 homolog |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A301-284A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | mouse (Expected: rat) |
Immunogen: | synthetic peptide. The epitope recognized by A301-284A maps to a region between residue 701 and 751 of mouse Nibrin using the numbering given in entry NP_038780.3 (GeneID 27354). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K10867 | Matching products |
UniProt ID : | Q9R207 | Matching products |
Gene ID | GeneID 27354 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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