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Reagents for Neurobiology


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Affordable reagents for neuroscience research.

Reagents for Neurobiology


Cat #UnitProduct Name
ABD-230505 mg BSB [(trans,trans)-1-Bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy) styrylbenzene]
ABD-230515 mg BTA-1 [2-(4-(methylamino)phenyl) benzothiazole]
ABD-2305225 mg BTA-2 [2-(4-(dimethylamino)phenyl)-6-methyl-benzothiazole]
ABD-230555 mg Chrysamine G
ABD-23056100 mg Congo Red *UltraPure grade*
ABD-214965 mg Di-2-ANEPEQ (JPW 1114)
ABD-214975 mg Di-8-ANEPPS
ABD-230545 mg Half chrysamine G
ABD-214831 mg MM 1-43 [N-(3-Triethylammoniumpropyl)-4-(4-(dibutylamino) styryl)pyridinium dibromide]
ABD-214891 mg MM 2-10 [N-(3-Triethylammoniumpropyl)-4-(4-(diethylamino) styryl)pyridinium dibromide]
ABD-214871 mg MM 4-64 [N-(3-Triethylammoniumpropyl)-4-(6-(4-(diethylamino)phenyl) hexatrienyl) pyridinium dibromide]
ABD-2149325 mg RH 155
ABD-214805 mg RH 237 [N-(4-Sulfobutyl)-4-(6-(4-(dibutylamino)phenyl) hexatrienyl) pyridinium, inner salt]
ABD-214855 mg RH 414 [N-(3-Triethylammoniumpropyl)-4-(4-(4-(diethylamino)phenyl) butadienyl) pyridinium dibromide]
ABD-214825 mg RH 421 [N-(4-Sulfobutyl)-4-(4-(4- (dipentylamino)phenyl) butadienyl) pyridinium, inner salt]
ABD-214951 mg RH 795
ABD-214951 mg RH 795
ABD-214925 mg TMA-DPH
ABD-230591 g Thioflavin S *UltraPure grade*
ABD-230601 g Thioflavin T *UltraPure grade*

Product Details


BSB [(trans,trans)-1-Bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy) styrylbenzene] A cell-permeable fluorescent probe that specifically binds to and labels intracellular beta-amyloid aggregates both in vitro (Ki = 400 nM) and in vivo. Useful as an antemortem diagnostic tool for animal models of Alzheimer’s disease.

BTA-1 [2-(4-(methylamino)phenyl)benzothiazole] BTA-1 is a fluorescent Thioflavin-T derivative that exhibits high affinity for amyloid deposits (Ki = 11 nM for Ab 40). It crosses the blood brain barrier and displays up to 50-fold higher affinity than Thioflavin-T, and used for selectively staining cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice.

BTA-2 [2-(4-(dimethylamino)phenyl)-6-methyl-benzothiazole] BTA-2 is an uncharged derivative of Thioflavin-T that exhibits high affinity for amyloid deposits [Ki = 143 nM for Ab(1-40)] and can cross the blood brain barrier. It displays up to 6-fold higher affinity than ThT and stains both plaques and neurofibrillary tangles in post mortem Alzheimer’s disease brain.

Chrysamine G Chrysamine G is a lipophilic, bis-salicylic acid analog of Congo Red that displays both high (Kd = 200 nM; Bmax = 1.13 moles per mole of Ab40) and low (Kd = 38.77 µM; Bmax = 23.10 moles per mole of Ab40) affinity binding sites for beta-amyloid (Ab) fibrils. It can cross the blood-brain barrier and serve as a useful probe for detecting senile plaques (Ab aggregate).

Congo Red *UltraPure grade* Congo red (CR) is the sodium salt of benzidinediazo-bis-1-naphtylamine-4-sulfonic acid. CR is water soluble, yielding a red colloidal solution. It is used to stain cytoplasm and erythrocyte stain in histology. Apple-green birefringence of CR stained preparates under polarized light is indicative for the presence of amyloid fibrils. Early diagnosis and classification of amyloid deposition and differentiation from other fibrillar deposits rely on routine CR-based histochemistry. This histology assay is widely used for the characterization of in vitro amyloid fibrils. In addition, CR is also used for fluorimetric examination of amyloid fibrils. Compared to CR in bright light CR fluorescence is simple to perform and more pronounced. Although not widely used, the CR fluorimetric method for detecting amyloid is simple to use with a high specificity and sensitivity, and may be applied successfully to frozen sections.

Di-2-ANEPEQ (JPW 1114) Di-2-ANEPEQ is used for monitoring fast membrane potential changes. ANEP dyes belong to the class of the fast-response membrane potential dyes. Their optical response is fast enough to detect transient membrane potential changes in excitable cells where they demonstrate a membrane potential-dependent shift in excitation spectra. This feature allows the measurement of membrane potential changes by excitation ratio. These dyes are weakly fluorescent in aqueous media, and become strongly fluorescent upon binding to lipophilic environments (such as membranes). In general, fast-response probes operate by means of a change in their electronic structure, and consequently their fluorescence properties, in response to a change in the surrounding electric field. Their optical response is sufficiently fast to detect transient (millisecond) potential changes in excitable cells, including single neurons, cardiac cells and intact brains. However, the magnitude of their potential-dependent fluorescence change is often small; fast-response probes typically show a 2-10% fluorescence change per 100 mV.

Di-8-ANEPPS Di-8-ANEPPS is widely used for monitoring fast membrane potential changes. ANEP dyes belong to the class of the fast-response membrane potential dyes. Their optical response is fast enough to detect transient membrane potential changes in excitable cells where they demonstrate a membrane potential-dependent shift in excitation spectra. This feature allows the measurement of membrane potential changes by excitation ratio. These dyes are weakly fluorescent in aqueous media, and become strongly fluorescent upon binding to lipophilic environments (such as membranes). Di-8-ANEPPS is less susceptible for cellular internalization than other ANEP dyes probably due to its sulfonate group. In general, fast-response probes operate by means of a change in their electronic structure, and consequently their fluorescence properties, in response to a change in the surrounding electric field. Their optical response is sufficiently fast to detect transient (millisecond) potential changes in excitable cells, including single neurons, cardiac cells and intact brains. However, the magnitude of their potential-dependent fluorescence change is often small; fast-response probes typically show a 2-10% fluorescence change per 100 mV.

Half chrysamine G A half-molecule of Chrysamine G, the well-known marker for beta-amyloid deposition, offers protection against beta-amyloid 25-35 and beta-amyloid 40-induced neuronal death at a concentration of 0.1-1 ?M. It is shown to cross the blood brain barrier. This molecule possesses minimal in vivo toxicity and displays low affinity to beta-amyloid40.

MM 1-43 [N-(3-Triethylammoniumpropyl)-4-(4-(dibutylamino)styryl)pyridinium dibromide] MM 1-43 is the abbreviation of our Membrane Marker 1-43, chemically called N-(3-triethylammoniumpropyl)-4-(4-(dibutylamino)styryl)pyridinium dibromide. It is a water-soluble membrane probe that belongs to the styryl dye family. It is widely used in cell biology and neurobiology since it has minimal toxicity to cells. MM 1-43 is virtually non-fluorescent in aqueous medium and strongly fluorescent upon binding to membrane. It is efficiently excited with standard fluorescein optical filters, and exhibits an intense fluorescent signal when associated with the plasma membrane. MM 1-43 has frequently been used to quantify exocytosis in neurons. Fluorescence imaging using MM 1-43 and related styryl dyes has provided invaluable insights into presynaptic function of synapses in culture preparations.

MM 2-10 [N-(3-Triethylammoniumpropyl)-4-(4-(diethylamino)styryl)pyridinium dibromide] MM 2-10 is the abbreviation of our Membrane Marker 2-10, chemically called N-(3-triethylammoniumpropyl)-4-(4-(diethylamino)styryl)pyridinium dibromide. It is a fluorescent membrane stain similar to MM 1-43, but slightly more hydrophilic. The release of MM 2-10 styryl dye is proportional to the time for which the synaptic vesicle is fused to the plasma membrane.

MM 4-64 [N-(3-Triethylammoniumpropyl)-4-(6-(4-(diethylamino)phenyl)hexatrienyl)pyridinium dibromide] MM 4-64 is the abbreviation of our Membrane Marker 4-64, chemically called N-(3-triethylammoniumpropyl)-4-(6-(4-(diethylamino)phenyl)hexatrienyl)pyridinium dibromide. It is a lipophilic styryl dye that is used as a vital stain to follow bulk membrane-internalization and transport to the vacuole in yeast. MM 4-64 is a sensitive reporter of vacuolar dynamics, detecting such events as segregation structure formation during mitosis, vacuole fission/fusion events, and vacuolar morphology in different classes of vacuolar protein sorting mutants. It can be used for detecting endosome to vacuole membrane transport in vitro.

RH 155 A neuron-tracing dye. It is used for monitoring membrane potential, synaptic activity and ion channel activity of neurons

RH 237 [N-(4-Sulfobutyl)-4-(6-(4-(dibutylamino)phenyl)hexatrienyl)pyridinium, inner salt] A neuron-tracing dye. It is used for monitoring membrane potential, synaptic activity and ion channel activity of neurons.

RH 414 [N-(3-Triethylammoniumpropyl)-4-(4-(4-(diethylamino)phenyl)butadienyl)pyridinium dibromide] A neuron-tracing dye. It is used for monitoring membrane potential, synaptic activity and ion channel activity of neurons.

RH 421 [N-(4-Sulfobutyl)-4-(4-(4- (dipentylamino)phenyl)butadienyl)pyridinium, inner salt] A neuron-tracing dye. It is used for monitoring membrane potential, synaptic activity and ion channel activity of neurons.

RH 795 A neuron-tracing dye. It is used for monitoring membrane potential, synaptic activity and ion channel activity of neurons.

TMA-DPH TMA-DPH is a fluorescent probe for membrane fluidity measurements. It is especially useful in the study of monolayer dynamics of lipoproteins and similar analogous systems. DPH and its derivatives (such as TMA-DPH) are cylinder-shaped and have fluorescence emission transition dipoles that are basically aligned parallel to their long molecular axis. As such, they are very sensitive to reorientation resulting from interactions with surrounding lipids. They are widely used in fluorescence polarization studies of rotational motion.

Thioflavin S *UltraPure grade* Thioflavin S is a mixture of compounds that results from the methylation of dehydrothiotoluidine with sulphonic acid. It is also used to stain Alzheimers plaques as ThT.

Thioflavin T *UltraPure grade* Thioflavin T (ThT), also called Basic Yellow 1 or CI 49005, is a benzothiazole salt. The dye is used to visualize plaques composed of beta-amyloid found in the brains of Alzheimers disease patients. When it binds to beta sheets, such as those in amyloid oligomers, the dye undergoes a characteristic 120 nm red shift of its excitation spectrum that may be selectively excited at 450 nm, resulting in a fluorescence signal at 482 nm. ThT binds rapidly and specifically to the anti-parallel beta-sheet fibrils formed from synthetic beta-amyloid (1-40), but does not bind to monomer or oligomeric intermediates. The binding of ThT does not interfere with the aggregation of beta-amyloid peptide into amyloid fibrils.
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