- Search results for Cay11070-25
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9 products were found matching "Cay11070-25"!
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Item number: Cay10770-25
The DNA methyltransferase 3 (DNMT3) family of DNMT proteins establish intial methylation of cytosines to form 5-methylcytosine at CpG (cytosine-phosphate-guanine) sites. Once methylation is established on DNA, DNMT1 protein is responsible for maintaining the CpG methylation pattern during chromosome replication. The...
Keywords: | DNMT3L, DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3-like |
Application: | Methylation studies |
MW: | 53,2 kD |
732.00€
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Item number: Cay10702-5
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). AZD...
Keywords: | 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine |
Application: | JAK2 inhibitor |
CAS | 935666-88-9 |
MW: | 348.8 D |
From 50.00€
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Item number: Cay11072-5
Bisindolylmaleimide III was developed as a protein kinase C (PKC) inhibitor with structural similarity to the nonspecific PKC inhibitor staurosporine. At 1 µM, bisindolylmaleimide III inhibits 93% of PKCalpha kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1 with...
Keywords: | BIM III, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
Application: | PKC inhibitor |
CAS | 137592-43-9 |
MW: | 384.4 D |
From 77.00€
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Item number: Cay11070-1
Bromodomain-containing 2 (BRD2) is a transcriptional regulator that is a member of the bromodomain and extra-terminal (BET) family. It is ubiquitously expressed and localizes to the nucleus. BRD2 is composed of two N-terminal bromodomains (BD1 and BD2) that bind acetylated lysine on histones, serving to couple...
Keywords: | BRD2, O27.1.1, O27.1.1, KIAA9001, Bromodomain-containing protein 2, Bromodomain-containing protein 2, Really interesting... |
Expressed in: | E.coli |
From 378.00€
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Item number: Cay11020-5
Bisindolylmaleimide II (BIM II) is a general inhibitor of all protein kinase C (PKC) subtypes with structural similarity to the nonspecific PKC inhibitor staurosporine. At 10 µM, BIM II inhibits 98% of PKCalpha kinase activity. Additionally, it inhibits PDK1 (IC50 = 14 µM), an important kinase in the insulin...
Keywords: | BIM II, 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione |
Application: | PKC inhibitor |
CAS | 137592-45-1 |
MW: | 438.5 D |
From 77.00€
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Item number: Cay11075-10
JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively). This cannabimimetic compound has frequently been found in herbal blends. JWH 018 N-(4,5-epoxypentyl) analog is distinguished by a terminal epoxide group on the alkyl...
Keywords: | JWH 018 epoxide, naphthalen-1-yl(1-(3-(oxiran-2-yl)propyl)-1H-indol-3-yl)methanone |
Application: | Analytical reference standard, synthetic cannabinoid analog |
CAS | 2365471-31-2 |
MW: | 355.4 D |
From 109.00€
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Lipid-based Drug Delivery Tools
Item number: Cay15107-250
1-Stearoyl-2-hydroxy-sn-glycero-3-PC is a saturated lysophosphatidylcholine. It increases IL-1beta production in isolated human blood monocytes when used at a concentration of 12.5 µM. Plasma levels of 1-stearoyl-2-hydroxy-sn-glycero-3-PC are decreased in patients with lung cancer.Formal Name:...
Keywords: | 1-Octadecanoyl-2-hydroxy-sn-glycero-3-phosphatidylcholine, 1-Stearoyl-2-hydroxy-sn-glycero-3-Phosphocholine,... |
Application: | Lysophosphatidylcholine |
CAS | 19420-57-6 |
MW: | 523.7 D |
From 84.00€
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Item number: Cay11700-250
Conessine is a steroidal alkaloid that has been found in H. antidysenterica and has diverse biological activities. It is active against a variety of Gram-positive and Gram-negative bacteria, including B. subtilis, S. aureus, M. luteus, and E. coli (MICs = 15.6-1,000 µg/disc in agar diffusion assays), the amoeba E....
Keywords: | Neriine, NSC 119994, Roquessine, Wrightine, N,N-dimethyl-con-5-enin-3beta-amine |
Application: | Allergy/Asthma studies |
CAS | 546-06-5 |
MW: | 356.6 D |
From 161.00€
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Item number: Cay21070-5
Bucindolol is a third-generation, non-selective beta-adrenergic receptor blocker that acts on both beta1 and beta2 receptors. Formulations containing beta-blockers, such as bucindolol, are used in managing chronic heart failure. Bucindolol is also a weak alpha1-adrenoceptor antagonist, which may be linked to a mild...
Keywords: | DL-Bucindolol, MJ13105-1, 2-[2-hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]-benzonitrile |
Application: | beta-adrenergic receptor antagonist |
CAS | 71119-11-4 |
MW: | 363.5 D |
From 60.00€
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