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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
B1095-04.100 | 100 µg | - | - |
3 - 19 business days* |
644.00€
|
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of... more
Product information "Anti-BID (BH3 Interacting Domain Death Agonist)"
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bid, a pro-apoptotic Bcl-2 family member, is cleaved by caspase-8 in response to apoptotic signals (4,5), exposing the Bcl-2 homology 3 (BH3) domain which is normally buried in the full-length protein (6). The cleaved complex is myris-toylated and translocated to the mitochondrial membrane where it may induce mitochondrial Bax and Bak to oligomerize (7,8). Applications: Can be used for detection of Bid by Western blot at 0.5 to 1ug/ml. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-p15 BID, Anti-p13 BID, Anti-p22 BID, Anti-p11 BID, Anti-BH3-interacting domain death agonist, Anti-BH3-interacting domain death agonist p11, Anti-BH3-interacting domain death agonist p13, Anti-BH3-interacting domain death agonist p15 |
Supplier: | United States Biological |
Supplier-Nr: | B1095-04 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Format: | Highly Purified |
Database Information
KEGG ID : | K04726 | Matching products |
UniProt ID : | P55957 | Matching products |
Gene ID | GeneID 637 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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