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Interleukin-6 (IL-6) and Inflammation

Interleukin-6 (IL-6) is a pro-inflammatory cytokine secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation.
In terms of host response to a foreign pathogen, IL-6 has been shown, in mice, to be required for resistance against the bacterium, Streptococcus pneumoniae. IL-6 is also a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction. Additionally, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.

Functions of IL-6

IL-6 is one of the most important mediators of fever and of the acute phase response. In the muscle and fatty tissue IL-6 stimulates energy mobilization which leads to increased body temperature. IL-6 can be secreted by macrophages in response to specific microbial molecules, referred to as pathogen associated molecular patterns (PAMPs). These PAMPs bind to highly important detection molecules of the innate immune system, called Toll-like receptors (TLRs), that are present on the cell surface (or in intracellular compartments) which induce intracellular signaling cascades that give rise to inflammatory cytokine production. IL-6 is also essential for hybridoma growth and is found in many supplemental cloning media. Inhibitors of IL-6 (including estrogen) are used to treat postmenopausal osteoporosis[1].

Interleukin-6 (IL-6) Recombinant Cytokine Proteins

Biomol offers competetively priced Interleukin-6: human IL-6, porcine IL-6 and rat IL-6.

Interleukin-6 Antibodies (Anti-IL-6)

Biomol offers a wide range of IL-6 antibodies, for WB, ELISA/EIA/RIA, ELISPOT, IP, ICC, IHC and Neutralization.

Interleukin-6 ELISA Kits (IL-6 EIA)

Biomol offers several IL-6 ELISA Kits: human 900-033 and mouse 900-045.

1. http://en.wikipedia.org/wiki/Interleukin-6

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