In Search of Putative FOXP3+ Cell Surface Markers
Neuropilin-1 (NRP-1), Folate Receptor4 (FR4), and GPR83.
Despite intense interest and scrutiny focused on FOXP3 as a key protein & master transcription factor, isolating and enriching for viable FOXP3 positive cells remains a challenge. Although cell separation/staining via CD4+CD25+ selection is commonly used, this technique has limited applications. Thus, surface markers specific for FOXP3 positive cells would be invaluable research tools as they would:
- Facilitate isolation & purification of viable Treg cells
- Distinguish naturally occurring CD4+CD25+cells from both naive and recently activated CD4+CD25-nonregulatory T cells
- Allow therapeutic manipulation of Treg cells
As the search for putative FOXP3+ markers continue, Neuropilin-1
, & FR4
have emerged as potential candidates. IMGENEX is excited to offer a panel of flow cytometric characterized antibodies against:
These antibodies are available in multiple sizes and conjugates. Select a link above to learn more about these products!
Flow Analysis Reagents