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G-Protein Coupled Receptor (GPCR) Antibodies


Imgenex offers more than 700 antibodies for detection of G-Protein Coupled Receptors (GPCR).
As one of the largest and most diverse protein families in nature, the G-protein coupled receptor (GPCR) superfamily play important roles in a variety of biological and pathological processes such as development and proliferation, neuromodulation, angiogenesis, metabolic disorders, inflammation, and viral infection. Not surprisingly, it is one of the most targeted protein families in pharmaceutical research today (Schlyer 2006).

All members of this superfamily share a similar seven transmembrane domain, but are grouped on the basis of shared sequence motifs into the following broad classes:

While research continues, it is evident that GPCRs are critical in countless biological functions--and disfunctions. While the emphasis is on their role in drug development, it is becoming increasingly clear that G-protein coupled receptors will play a critical role as indicators of disease with diagnostic and prognostic potential. IMGENEX carries over 700 IHC, WB, and flow validated GPCR antibodies. View our complete antibody list grouped by class and family. Also see our complete list of Tissue Microarray slides--perfect for GPCR localization studies.

The pharmaceutical industry has focused on development of modulators to this protein family, but GPCRs also represent an attractive target as biomarkers. Recent studies have implicated endothelin receptors, chemokine receptors and lysophosphatidic acid receptors in tumorgenesis and metastasis, and a recent in silico analysis found a number of GPCRs that were up-regulated in various cancers which suggests not only targets of therapeutic value, but of diagnostic and prognostic value as well. A summary of these up-regulated receptors is below.

Just click the link here: GPCR. The following link lists these as well as GPCR antibodies of other companies:

GPCR Antibodies

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