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High Activity VEGF165


VEGF-165 (HuXp) recombinant human cytokine authentic - human cell expressed.
VEGF165 is a member of the cysteine-knot growth factor superfamily. This cytokine stimulates proliferation and survival of endothelial cells, and promote angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF165 plays a prominent role in normal and pathological angiogenesis. It has been demonstrated that inhibition of VEGF165 activity by treatment with a monoclonal antibody specific for VEGF165 can suppress tumor growth in vivo.

Currently, commercially available VEGF165 proteins are produced from non-human cells including E. coli and insect cells. HumanZyme has produced VEGF165 (HuXp) from engineered human 293 cells. The E. coli expressed protein is a monomer - dimer mixture and has a molecular mass of 18 and 34 kD in SDS-PAGE. This compares with the VEGF165 (HuXp) which migrates as a glycosylated band of 36 kD due to glycosylation and dimerization.

The bioactivity of VEGF165 (HuXp) was determined by its ability to induce proliferation of human umbilical vein endothelial cells. These results indicate VEGF165 (HuXp) is 5-fold more active than the E. coli expressed protein (ED50 of 1.6 ng/mL for HumaXpress expressed protein vs 7.9 ng/mL for E. coli expression).

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