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Activin A Human Cell Expressed


Authentic Activin A (HuXp) expressed in human cells.
Activin A belongs to the TGF-ß super-family and exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Activin A is a disulfide-linked dimeric protein produced as precursor with an amino-terminal propeptide that is enzymatically cleaved to release the carboxy-terminal bioactive ligand. Due to complex post-proteolytic modification processes, yield from insect cell and CHO cell expression systems is low and as a result bulk volume is uneconomical and not readily available. HumanZyme has produced Activin AHuXp in a stable cell culture of engineered human HEK293 cells. The protein is expressed as a disulfide-linked dimer of 26 kD and, due to the scalability of the stable culture, can be cost-effectively produced. As shown in the figure, Activin A (HuXp) is highly purified while a commercially sourced cytokine expressed in CHO exhibits contamination by the precursor and several other proteins.

Activin A (HuXp) was assayed by it’s ability to inhibit the proliferation of murine MPC-11 cells. The results indicate the activity of HumaXpress™ Activin A is comparable to that of the CHO expressed version. HumanZyme cytokines are manufactured to high quality standards and provide high biological activity, lot-to-lot consistency and low endotoxin levels.

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