Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
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Momelotinib
Artikelnummer: SYN-1035-M005
Soluble in DMSO. CYT387 is selective inhibitor of JAK1 and JAK2 kinases including the JAK2V617F mutant . Using ATP kinase assays IC(50) values for JAK1 (11nm), JAK2, (18nM), JAK2, JAK2V617F (23nM) JAK3 (155nM), and TYK2 (17nM). In testing kinase arrays, CYT387 also had activity (defined as an IC(50) < 100nM)...
| Schlagworte: | CYT387, Momelotinib |
| Anwendung: | JAK1 / JAK2 inhibitor |
| CAS | 1056634-68-4 |
| MW: | 414,5 D |
ab 106,00 €
Merck-5
Artikelnummer: SYN-1054-M001
Soluble in DMSO. Merck 5, also known as Pyridone 6, is a potent and reversible ATP-competitive inhibitor of the JAK kinases (JAK1, JAK2, JAK3, and Tyk2) with IC(50) values in the low anomolar range. At higher values (IC(50) >100nM) Merck 5 also can inhibit ERK kinase family and appear to block IL-2 and IL-4...
| Schlagworte: | Pyridone 6 |
| Anwendung: | JAK / Tyk2 inhibitor |
| CAS | 457081-03-7 |
| MW: | 309,3 D |
ab 300,00 €
Vandetanib
Artikelnummer: SYN-1090-M005
Soluble in DMSO or ethanol. Vandetanib is a tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR, IC(50) of 40nM) and the epidermal growth factor receptor (EGFR). Target: EGFR - VEGFR2 , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | ZD6474, Zactima, Vandetanib |
| Anwendung: | EGFR / VEGFR2 inhibitor |
| CAS | 443913-73-3 |
| MW: | 475,4 D |
ab 79,00 €
R788 disodium salt
Artikelnummer: SYN-1122-M001
Slightly soluble (<1mg/ml) in DMSO or ethanol. Tamatinib effectively inhibits BCR signaling in vivo, resulting in reduced proliferation and survival of the malignant B cells and significantly prolonged survival of the treated animals. Target: BCR , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | Fostamatinib, Tamatinib fosdium, FosD, R-788 |
| Anwendung: | Syk inhibitor |
| CAS | 1025687-58-4 |
| MW: | 624,5 D |
ab 139,00 €
Bayer-18
Artikelnummer: SYN-1130-M001
Soluble in DMSO. Bayer-18 is a selective TYK2 inhibitor, with an IC(50) of 18.7nM on TYK2 as measured by TYK2 HTRF assays. The compound shows 1000 fold selectivity against JAK2, CDK and KDR kinases in similar HTRF assays. Target: TYK2 , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | Bayer18 |
| Anwendung: | TYK2 inhibitor |
| CAS | 1251752-12-1 |
| MW: | 390,5 D |
ab 250,00 €
Bafetinib
Artikelnummer: SYN-1179-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl, Lyn inhibitor with IC(50) values of 5.8nM and 19nM, respectively.
| Schlagworte: | NS-187, INNO-406 |
| Anwendung: | Bcr-Abl / Lyn inhibitor |
| CAS | 859212-16-1 |
| MW: | 576,6 D |
ab 132,00 €
Canertinib
Artikelnummer: SYN-1030-M010
Soluble in DMSO or ethanol. Canertinib is an orally bio-available EGFR inhibitor with potential anti-neoplastic and radio-sensitizing activities. It has IC(50) values of 1.5nM and 9.0nM against EGFR and ErbB2 respectively, with no activity against PDGFR, FGFR, InsR, PKC, or CDK1/2/4. Target: EGFR , Kinase Group:...
| Schlagworte: | CI1033, PD-183805 |
| Anwendung: | EGFR inhibitor |
| CAS | 267243-28-7 |
| MW: | 486 D |
ab 66,00 €
KU-0063794
Artikelnummer: SYN-1050-M005
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. KU0063794 is a highly specific inhibitor of the mammalian target of rapamycin (mTOR). It inhibits both mTORC1 and mTORC2 with an IC(50) of approximately 10nM. Target: mTOR , Kinase Group: Atypical (PIKK) , Substrate: Serine-Threonine
| Schlagworte: | KU0063794 |
| Anwendung: | mTOR inhibitor |
| CAS | 938440-64-3 |
| MW: | 465,6 D |
ab 92,00 €
PIK-75
Artikelnummer: SYN-1067-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. PIK-75 is a PI3K inhibitor displaying selectivity for the p110alpha isoform (IC(50) of 6nM). PIK-75 blocks the phosphorylation of PKB induced by insulin. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | PIK75 |
| Anwendung: | PI3K-beta inhibitor |
| CAS | 372196-67-3 |
| MW: | 452,3 D |
ab 66,00 €
Afatinib
Artikelnummer: SYN-1100-M001
Soluble in DMSO or ethanol. Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines...
| Schlagworte: | Tovok, BIBW-2992 |
| Anwendung: | EGFR / HER2 inhibitor |
| CAS | 439081-18-2 |
| MW: | 486 D |
ab 106,00 €
GLPG0634
Artikelnummer: SYN-1158-M001
Soluble in DMSO. GLPG0634 is a novel and specific inhibitor of JAK1 and JAK2 with IC(50) of 10nM and 28nM respectively measured by in vitro kinase assays (ATP 2µM). In particular GLPG0634, while being a potent inhibitor of JAK1 and JAK2 does not inhibit TYK2 or JAK3, and GLPG0634 exhibits a dramatically improved in...
| Schlagworte: | GLPG-0634, Filgotinib |
| Anwendung: | JAK1 / JAK2 inhibitor |
| CAS | 1206161-97-8 |
| MW: | 425,5 D |
ab 250,00 €
LEE011
Artikelnummer: SYN-1213-M001
Solid. Soluble in DMSO. Orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathways, with potential antineoplastic activity. Specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation...
| Schlagworte: | LEE-011, Ribociclib |
| Anwendung: | CDK4/CDK6 inhibitor |
| CAS | 1211441-98-3 |
| MW: | 434,5 D |
ab 66,00 €