Purity: >99%. The detergent is <7% beta isomer.

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

function:Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.,similarity:Belongs to...

AKOS B018304 is an arylalkylidene derivative of 1,3-thiazolidin-4-one. It inhibits the binding of DeltaFosB to an oligonucleotide containing the activator protein-1 (AP-1) consensus site, Cdk5-AP-1, in a cell-free assay (IC50 = 5.5 µM). AKOS B018304 (12.5 µM) induces DeltaFosB- and DeltaFosB/JunD-mediated gene...

Heat shock protein 70s (Hsp70s) are abundant and stress-inducible 70 kDa molecular chaperone proteins encoded by a highly conserved, multigene family. They are monomeric proteins that can be divided into two functional domains: an N-terminal ATPase domain and a substrate binding domain that contains a highly...