Anti-EYA2 (IHC)

Anti-EYA2 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00736-T 10 µl (500 ng) -

2 - 8 business days*

164.00€
IHC-00736 100 µl (5 µg) -

2 - 8 business days*

623.00€
 
Protein function: Functions both as protein phosphatase and as transcriptional coactivator for... more
Product information "Anti-EYA2 (IHC)"
Protein function: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2, in this it is functionally redundant with EYA1 (PubMed:12500905). [The UniProt Consortium]
Keywords: Anti-EAB1, Anti-EYA2, Anti-Eyes absent homolog 2
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00736

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: bovine, horse, orangutan, monkey, gorilla, chimpanzee, northern white-cheeked gibbon, little brown bat, small-eared galago)
Immunogen: Synthetic peptide. The epitope recognized by IHC-00736 maps to a region between residue 100 and 150 of human eyes absent homolog 2 using the numbering given in entry NP_005235.3 (GeneID 2139).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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