Anti-JMY (IHC)

Anti-JMY (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00718-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00718 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin... more
Product information "Anti-JMY (IHC)"
Protein function: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location. [The UniProt Consortium]
Keywords: Anti-JMY, Anti-Junction-mediating and -regulatory protein
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00718

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse, bovine, dog, guinea pig_10141, panda, monkey, gorilla, chimpanzee, northern white-cheeked gibbon, little brown bat)
Immunogen: synthetic peptide. The epitope recognized by IHC-00718 maps to a region between residue 1 and 50 of human junction mediating and regulatory protein using the numbering given in entry NP_689618.3 (GeneID 133746).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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