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Anti-phospho-SMC1 (Ser957)

ART NR.: A300-045A (100 µl / 100 µg)

Hersteller: Bethyl

Datenblatt



MSDS

Anwendungen: WB, IP, PLA

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human (expected: bovine, dog, rabbit, guinea pig, swine, panda, orangutan, rhesus monkey, white-tufted-ear marmoset, crab-eating macaque, european domestic ferret, african elephant, naked mole rat, northern white-cheeked gibbon)

Immunogen: synthetic phospho-peptide. Immunogen for A300-045A was a phosphorylated synthetic peptide, which represented a portion of human Structural Maintenance of Chromosomes 1 (GeneID 8243) around serine 957 according to the numbering given in entry NP_006297.2.

Lagerung: +4°C

Versand: +4°C

UniProt ID: Q14683 | Suche mit UniProt ID

KEGG ID: K06636 | Suche mit KEGG ID

Schlagworte: Anti-phospho-SMC-1A (pS957), Anti-phospho-SMC1A, Anti-phospho-SMC1L1 - Structural Maintenance of Chromosomes-1 Like 1

A300-045A

100 µl (100 µg)

380 €

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Bemerkungen: Structural maintenance of chromosomes (SMC) proteins are part of the cohesin and condensin multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. The core cohesin complex includes a heterodimer of SMC1 and SMC3 that functions by forming a ring-like structure that holds sister chromatids together. Cohesin is important to sister chromatid separation and segregation during mitosis and meiosis and also plays a role in double-strand break repair by homologous recombination. Alternate designations for SMC1 include SMC1-alpha protein, SMC1A, DXS423E, KIAA0178, SB1.8, SMC1L1, MGC138332, and DKFZp686L19178.

Spezifikationen

Phospho SMC1 (S957) Antibody

Rabbit anti-Phospho SMC1 (S957) Antibody, Affinity Purified
Phospho SMC1 (S957) AntibodyPhospho SMC1 (S957) Antibody
Phospho SMC1 (S957) AntibodyPhospho SMC1 (S957) Antibody

Gene and Protein Information

Citations

Kalifa L et al., DNA Double-Strand Breaks Activate ATM Independent of Mitochondrial Dysfunction in A549 Cells. Free Radic Biol Med. 2014 Jul 15. pii: S0891-5849(14)00328-1. WB
PubMed: 25048973
Leonard JM et al., Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability. J Cell Biol. 2008 Nov 3;183(3):385-91. WB
PubMed: 18955550
Murakawa Y et al., Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells. Cancer Res. 2007 Sep 15;67(18):8536-43. ICC
PubMed: 17875693
Matsuoka S et al., ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. IP
PubMed: 17525332
Rai R et al., BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell. 2006 Aug;10(2):145-57.
PubMed: 16872911
Musio A et al., SMC1 involvement in fragile site expression. Hum Mol Genet. 2005 Feb 15;14(4):525-33. WB
PubMed: 15640246
Mochan TA et al., 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res. 2003 Dec 15;63(24):8586-91. WB
PubMed: 14695167
Goldberg M et al., MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature. 2003 Feb 27;421(6926):952-6. WB
PubMed: 12607003
Yazdi PT et al., SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 2002 Mar 1;16(5):571-82. WB, IP
PubMed: 11877377

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