Antikörper Anti-phospho-RB1, (S807) (Retinoblastoma-associated Protein, pRb, Rb, PP110, P105-Rb)

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Name/Antigen	KLON	WIRT	TYP	ISOTYP	SPEZ. REAKT.	FORMAT	ANWENDUNG	HERSTELLER	KAT #	MENGE	PREIS

Anti-phospho-RB1, (S807) (Retinoblastoma-associated Protein, pRb, Rb, PP110, P105-Rb)		Rabbit > sec. Ab	Pab	IgG	human	affinity purified	ELISA IHC	USBio	R1660-05K2.100	100 µg Buy Bulk	417 €
Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. [The UniProt Consortium] Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding S807 of human RB (KLH). Datenblatt ansehen Kat #: R1660-05K2.100 Menge: 100 µg Buy Bulk Preis: 417 € UniProt ID: P06400 (Protein knowledgebase) Geninformationen: GeneID 5925 Antikörper-Konjugations-Kits Schlagworte: Anti-phospho-pp110, Anti-phospho-p105-Rb, Anti-phospho-Retinoblastoma-associated protein, antibody, antibodies, Antikörper Loading ... zurück							Weitere Produkte für dieses Protein: Antibodies Anti-phospho-Rb (Ser249), Kat #: WA-AP3233a Anti-phospho-RB (Ser608), Kat #: WA-AP3235a Anti-phospho-RB (Ser612), Kat #: WA-AP3236a Anti-phospho-Rb (Ser780), Kat #: WA-AJ1682b Anti-phospho-Rb (Ser780), Kat #: WA-AP3237a Anti-phospho-Rb (Ser788), Kat #: WA-AP3238a Anti-phospho-RB (Ser795), Kat #: WA-AP3239a Anti-phospho-Rb (Ser811), Kat #: WA-AP3241a Anti-phospho-Rb (Thr356), Kat #: WA-AJ1682c Anti-phospho-Rb (Thr373), Kat #: WA-AJ1682d more Enzymes & Proteins RB Protein, Kat #: BPS-40595 siRNA RB1 predesign siRNA, Kat #: WA-RI14468 Primers RB1, Human retinoblastoma 1, Real Time PCR Primer Set, Kat #: VHPS-7676 Peptides Phospho-Rb-S249 Antibody Blocking Peptide, Kat #: WA-BP3233a Phospho-RB-S608 Antibody Blocking Peptide, Kat #: WA-BP3235a Phospho-RB-S612 Antibody Blocking Peptide, Kat #: WA-BP3236a Phospho-Rb-S780 Antibody Blocking Peptide, Kat #: WA-BP3237a Phospho-Rb-S788 Antibody Blocking Peptide, Kat #: WA-BP3238a Phospho-RB-S795 Antibody Blocking Peptide, Kat #: WA-BP3239a Phospho-Rb-T826 Antibody Blocking Peptide, Kat #: WA-BP3244a PhosphoRb-S811 Antibody Blocking Peptide, Kat #: WA-BP3241a RB1 Antibody (C-term) Blocking Peptide, Kat #: WA-BP8575b RB1 Antibody (S608) Blocking Peptide, Kat #: WA-BP6265e Relevant Pathways: Cell cycle HTLV-I infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Pancreatic cancer Glioma Prostate cancer Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Products for: RB1 - retinoblastoma-associated protein Antibodies (73) Enzymes & Proteins (1) Peptides (10) Primers (3) siRNA (1)

Datenbank vom 23.05.2013, 14:27 Uhr

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