Autoantibodies to histone antigens have been described in patients with idiopathic and drug-induced SLE, rheumatoid arthritis, and other conditions. The presence of autoantibodies to histones are frequently found in several rheumatic disorders (1). In one study, the predominant responses to histones in SLE sera were...

Autoantibodies to histone antigens have been described in patients with idiopathic and drug-induced SLE, rheumatoid arthritis, and other conditions. The presence of autoantibodies to histones are frequently found in several rheumatic disorders (1). In one study, the predominant responses to histones in SLE sera were...

The phosphorylation of histone H3 plays an important role in gene expression, chromatin remodeling, chromosome condensation and cell division. Histone H3 phosphorylation may initiate at different phases of the cell division in different organisms. Metaphase chromosomes are always found to be heavily phosphorylated....

Applications: , Suitable for use in Western Blot, Beadlyte? Histone-Peptide Specificity Assay and Chromatin IP. Other applications not tested. Recommended Dilution: Western Blot Analysis: A 1:1000-1:5000 dilution detected acetyl-Histone H3 (Lys14) in acid extracts from sodium butyrate treated HeLa cells , Beadlyte?...

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further...