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Anti-phospho-BRCA1 (Ser1466)

ART NR.: A300-011A (100 µl | 100 µg)

Hersteller: Bethyl

Datenblatt



MSDS

Anwendungen: WB

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human (expected: orangutan, gorilla, chimpanzee, white-tufted-ear marmoset, bornean orangutan)

Immunogen: synthetic phospho-peptide. Immunogen for A300-011A was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1466 according to the numbering given in entry NP_009225.1.

Lagerung: +4°C

Versand: +4°C

UniProt ID: P38398 | Suche mit UniProt ID

KEGG ID: K10605 | Suche mit KEGG ID

Schlagworte: EC=6.3.2.-, Anti-phospho-BRCA1, Anti-phospho-BRCA (pS1466), Anti-phospho-Breast Cancer Gene 1, Anti-phospho-Breast Cancer 1, Anti-phospho-Early Onset, Anti-phospho-Breast-Ovarian Cancer Susceptibility

A300-011A

100 µl (100 µg)

410 €

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Bemerkungen: BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. BRCA1 is also known as breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53, IRIS, PSCP, BRCAI, and BRCC1.

Spezifikationen

Phospho BRCA1 (S1466) Antibody

Rabbit anti-Phospho BRCA1 (S1466) Antibody, Affinity Purified

Gene and Protein Information

Citations

Matsuoka S et al., ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. IP
PubMed: 17525332

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