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Anti-phospho-BRCA1 (Ser1387)

ART NR.: A300-007A (100 µl | 100 µg)

Hersteller: Bethyl

Datenblatt



MSDS

Anwendungen: WB, IP

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human (expected: horse, panda, orangutan, gorilla, chimpanzee, bornean orangutan, northern white-cheeked gibbon)

Immunogen: synthetic phospho-peptide. Immunogen for A300-007A was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1387 according to the numbering given in entry NP_009225.1.

Lagerung: +4°C

Versand: +4°C

UniProt ID: P38398 | Suche mit UniProt ID

KEGG ID: K10605 | Suche mit KEGG ID

Schlagworte: EC=6.3.2.-, Anti-phospho-BRCA1, Anti-phospho-BRCA (pS1387), Anti-phospho-Breast Cancer Gene 1, Anti-phospho-Breast Cancer 1, Anti-phospho-Early Onset, Anti-phospho-Breast-Ovarian Cancer Susceptibility

A300-007A

100 µl (100 µg)

410 €

In Warenkorb aufnehmen


Bemerkungen: BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. BRCA1 is also known as breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53, IRIS, PSCP, BRCAI, and BRCC1.

Spezifikationen

Phospho BRCA1 (S1387) Antibody

Rabbit anti-Phospho BRCA1 (S1387) Antibody, Affinity Purified

Gene and Protein Information

Citations

Krenciute G, Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death. J Biol Chem. 2013 Jul 12;288(28):20547-57. WB, IP
PubMed: 23723067
Matsuoka S et al., ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. IP
PubMed: 17525332
Mu JJ et al., A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J Biol Chem. 2007 Jun 15;282(24):17330-4. IP
PubMed: 17478428

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