ART NR.: A300-248A (100 µl)
Anwendungen: WB, IP
Format: antigen affinity purified
Immunogen: synthetic peptide. The epitope recognized by A300-248A maps to a region between residues 325 and 375 of human tumor protein p53 using the numbering given in SwissProt entry P04637 (GeneID 7157).
UniProt ID: P04637
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Schlagworte: Anti-p53, Anti-TP53, Anti-TRP53, Anti-tumor protein p53, Anti-Li-Fraumeni syndrome.
p53 is a tumor suppressor protein that is mutated or inactivated in over 50 percent of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis. Alternate names for p53 include cellular tumor antigen p53, tumor suppressor p53, phosphoprotein p53, antigen NY-CO-13, TP53, TRP53, and Li-Fraumeni syndrome.