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Anti-p53

ART NR.: A300-247A (100 µl)

Hersteller: Bethyl

Datenblatt

Anwendungen: WB, IP, FC, PLA

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human

Immunogen: synthetic peptide. The epitope recognized by A300-247A maps to a region between residues 50 and 100 of human tumor protein p53 using the numbering given in SwissProt entry P04637 (GeneID 7157).

UniProt ID: P04637
Suche mit UniProt ID

Schlagworte: Anti-p53, Anti-TP53, Anti-TRP53, Anti-tumor protein p53, Anti-Li-Fraumeni syndrome.

100 µl

349 €

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Bemerkungen: p53 is a tumor suppressor protein that is mutated or inactivated in over 50 percent of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis. Alternate names for p53 include cellular tumor antigen p53, tumor suppressor p53, phosphoprotein p53, antigen NY-CO-13, TP53, TRP53, and Li-Fraumeni syndrome.

Die Preise für Antikörper verstehen sich exkl. Versandkosten, eventuell anfallender Kühlmittelpauschale sowie der jeweils geltenden Mehrwertsteuer.





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