8 products were found matching "P1001-28Z1.100"!

The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (1). p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro (2,3). DNA...

Fusion Partners: Spleen cells from immunized BALB/c mice were fused with cells of the mouse X63Ag8.653 myeloma cell line. Recommended Negative Controls: Mouse IgM Negative Control , Applications:, Flow Cytometry: Neat., use 10ul to label 10ee6 cells or 100ul whole blood. Membrane permeabilization is required. ,...

P53 is a 339 amino acid protein (53kD) that is thought to act as a tumor suppressor gene. p53 is a DNA-binding protein, and missense mutation of the gene can lead to loss of its DNA-binding functions, and subsequent inactivation of p53 may be a contributing factor in tumorigenesis. Mutation of p53 occurs at many...

The p53 gene is located on human chromosome 17p13.1. Mutation and/or allelic loss of this gene is one of the causes of the occurrence of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. P53 binds to a DNA consensus sequence, the p53 response element, and it...

Human p53 is a tumor suppressor protein which is mutated in many cancers. p53 expression has been linked to apoptosis caused by DNA-damaging agents and may have a role in cell-mediated cytotoxicity. Applications: Suitable for use in Western Blot, Flow Cytometry and Immunohistochemistry. Other applications not...

p53 is a 53kD protein that forms tetramers and functions as a tumor suppressor and transcriptional activator of genes that inhibit growth and/or invasion, cell cycle checkpoint after irradiation, DNA repair, apoptotic induction, signal transduction, and cell adhesion. This protein is localized to the nucleus when...

Applications:, Suitable for use in ELISA, Immunoflourescence, Immunohistochemistry, Flow Cytometry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Immunohistochemistry: frozen sections, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for...

p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein. p53 senses DNA damage and possibly facilitates repair. Mutation involving p53 is found in a wide...