Anti-p127-DDB1 (internal)

Anti-p127-DDB1 (internal)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
100-401-A09 100 µl - -

6 - 10 business days*

684.00€
 
Protein function: Required for DNA repair. Binds to DDB2 to form the UV- damaged DNA-binding... more
Product information "Anti-p127-DDB1 (internal)"
Protein function: Required for DNA repair. Binds to DDB2 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin- protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2. [The UniProt Consortium]
Keywords: Anti-XAP1, Anti-DDBa, Anti-DDB1, Anti-XPCe, Anti-XAP-1, Anti-XPE-BF, Anti-UV-DDB 1, Anti-DDB p127 subunit, Anti-XPE-binding factor, Anti-HBV X-associated protein 1, Anti-DNA damage-binding protein a, Anti-DNA damage-binding protein 1
Supplier: Rockland Immunochemicals
Supplier-Nr: 100-401-A09

Properties

Application: ELISA, IHC, IP, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 198-213 of human DDB1 (internal)
MW: 127 kD
Format: Serum

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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