Cdc14, also known as duel specificity phosphatase, is a protein phosphatase originally discovered in yeast that plays an important role in cell cycle regulation, including exit from mitosis. Throughout G1, S and G2 phases, Cdc14 is located in the nucleolus, at the beginning of anaphase, the protein is redistributed...

Cdc14, also known as duel specificity phosphatase, is a protein phosphatase originally discovered in yeast that plays an important role in cell cycle regulation, including exit from mitosis (1). Throughout G1, S and G2 phases, Cdc14 is located in the nucleolus, at the beginning of anaphase, the protein is...

The Cdc6 protein is an essential component of pre-replication complexes (preRCs), which assemble at origins of DNA replication during the G1 phase of the cell cycle. Cdc6 participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. It has been concluded that expression of...