Anti-c-Maf

Anti-c-Maf
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A300-613A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A300-613A 100 µl (100 µg) -

2 - 8 business days*

600.00€
 
Protein function: Acts as a transcriptional activator or repressor. When overexpressed, represses... more
Product information "Anti-c-Maf"
Protein function: Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)- mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf- responsive element binding. [The UniProt Consortium]
Keywords: Anti-Maf, Anti-Maf2, Anti-Proto-oncogene c-Maf, Anti-Transcription factor Maf, Anti-V-maf musculoaponeurotic fibrosarcoma oncogene homolog
Supplier: Bethyl Laboratories
Supplier-Nr: A300-613A

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: mouse (Expected: bovine)
Immunogen: synthetic peptide. The epitope recognized by A300-613A maps to a region between residue 150 and 200 of mouse v-maf musculoaponeurotic fibrosarcoma oncogene homolog (c-Maf) using the numbering given in entry NP_001020748.2 (GeneID 17132).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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