Anti-c-Cbl

Anti-c-Cbl
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-337A-T 10 µl (2 µg) -

2 - 8 business days*

164.00€
A302-337A 100 µl -

2 - 8 business days*

588.00€
 
Protein function: Adapter protein that functions as a negative regulator of many signaling... more
Product information "Anti-c-Cbl"
Protein function: Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. [The UniProt Consortium]
Keywords: Anti-CBL, Anti-CBL2, Anti-Proto-oncogene c-Cbl, Anti-RING finger protein 55, Anti-Signal transduction protein CBL, Anti-E3 ubiquitin-protein ligase CBL, Anti-RING-type E3 ubiquitin transferase CBL, Anti-Casitas B-lineage lymphoma proto-oncogene
Supplier: Bethyl Laboratories
Supplier-Nr: A302-337A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque)
Immunogen: synthetic peptide. The epitope recognized by A302-337A maps to a region between residue 575 and 625 of human Casitas B-lineage lymphoma proto-oncogene using the numbering given in entry NP_005179.2 (GeneID 867).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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