- Search results for 107-ASYN
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7 products were found matching "107-ASYN"!
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Item number: SYN-1077-M001
Soluble in DMSO or ethanol. SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity. Target: ARaf -...
Keywords: | SB-590885 |
Application: | BRAF inhibitor |
CAS | 405554-55-4 |
MW: | 453,5 D |
From 106.00€
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Item number: SYN-1078-M001
Soluble in DMSO. SD-06 is a p38 MAP kinase inhibitor. It inhibits p38alpha with an IC(50) value of 170nM and inhibits LPS-stimulated TNF-release in rats. Target: p38 , Kinase Group: CMGC , Substrate: Serine-Threonine
Keywords: | SD06 |
Application: | p38 inhibitor |
CAS | 271576-80-8 |
MW: | 397,9 D |
From 250.00€
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Item number: SYN-1070-M001
Soluble in DMSO or ethanol. Purvalanol B is a cyclin-dependent kinase inhibitor with IC(50) values of 6, 6, 9, > 10,000, and 6nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35, respectively. Purvalanol B has also been shown to have anti-proliferative properties, mediated by p42/p44...
Keywords: | NG95 |
Application: | Cyclin-dependent kinase inhibitor inhibitor |
CAS | 212844-54-7 |
MW: | 432,9 D |
From 66.00€
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Item number: SYN-1072-M001
Soluble in DMSO or ethanol. The cytokine Tumor necrosis factor-alpha (TNF-alpha) is secreted by activated monocytes/macrophages and T lymphocytes and has been implicated in several disease states, including rheumatoid arthritis, inflammatory bowel disease, septic shock, and osteoporosis. Monocyte/macrophage...
Keywords: | RWJ67657 |
Application: | p38 inhibitor |
CAS | 215303-72-3 |
MW: | 425,5 D |
From 66.00€
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Item number: SYN-1079-M001
Soluble in DMSO or ethanol. SD169 is an orally available, ATP-competitive, isoenzyme-selective Mitogen-Activated Protein Kinase (MAPK) inhibitor. It is 38 times more potent against p38alpha MAP kinase (IC(50) of 3.2nM) over p38beta MAP kinase (IC(50) of 122nM). Target: MAPK - p38 , Kinase Group: CMGC , Substrate:...
Keywords: | SD169 |
Application: | p38 alpha inhibitor |
CAS | 1670-87-7 |
MW: | 160,2 D |
From 66.00€
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Item number: SYN-1071-M001
Soluble in DMSO. GSK429286A is a potent and selective inhibitor of Rho-associated kinase (ROCK1), with an IC(50) of 14nM. It is orally available and has been shown to dramatically reduce mean arterial pressure in spontaneously hypertensive rats. Target: ROCK , Kinase Group: AGC , Substrate: Serine-Threonine
Keywords: | GSK-429286A, RHO-15 |
Application: | ROCK inhibitor |
CAS | 864082-47-3 |
MW: | 432,4 D |
From 119.00€
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Item number: SYN-1076-M001
Soluble in DMSO. The p38 mitogen-activated protein kinase (MAPK) signaling pathway is activated by numerous inflammatory mediators and environmental stresses. SB-242235 is a potent and moderately selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or...
Keywords: | SB-242235 |
Application: | p38 inhibitor |
CAS | 193746-75-7 |
MW: | 353,4 D |
From 250.00€
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