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Anti-acetyl-p53 (Lys386)

ART NR.: ABD-8D0017.50 (50 µg)

Hersteller: AAT Bioquest

Datenblatt



Manual



MSDS

Anwendungen: IHC, IF, ELISA

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human

Immunogen: synthetic peptide

Lagerung: +4°C

Versand: +4°C

UniProt ID: P04637
Suche mit UniProt ID

Geninformationen: GeneID 7157

Schlagworte: Anti-P53, Anti-TP53, Anti-Antigen NY-CO-13, Anti-Phosphoprotein p53, Anti-Tumor suppressor p53, Anti-Cellular tumor antigen p53

ABD-8D0017.50

50 µg

195 €

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Bemerkungen: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Spezifikationen

aat_bioquest_datasheet_parse.php?nr=ABD-8D0017.50&ak=1
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