Anti-ZCCHC11 (IHC)

Anti-ZCCHC11 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00730-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00730 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short... more
Product information "Anti-ZCCHC11 (IHC)"
Protein function: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency. Does not bind RNA directly, but recruited to RNA targets by RNA-binding protein LIN28A. Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult. [The UniProt Consortium]
Keywords: Anti-ZCCHC11, Anti-TUTase 4, Anti-KIAA0191, EC=2.7.7.52, Anti-Terminal uridylyltransferase 4, Anti-Zinc finger CCHC domain-containing protein 11
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00730

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: dog, panda, gorilla, chimpanzee, naked mole rat, chinese hamster, ferret, white-tufted-ear marmoset)
Immunogen: Synthetic peptide. The epitope recognized by IHC-00730 maps to a region between residue 250 and 300 of human zinc finger, CCHC domain containing 11 using the numbering given in entry NP_056084.1 (GeneID 23318).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-ZCCHC11 (IHC)"
Write a review
or to review a product.
Viewed