Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair, Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation, Lys-29-linked is involved in lysosomal degradation, Lys-33-linked is involved in kinase modification, Lys-48-linked is involved in protein degradation via the proteasome, Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Immunogen: synthetic peptide
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Kat #: ABD-8C0385.50
Menge: 50 µgBuy Bulk
Preis: 195 €
UniProt ID: P0CG47 (Protein knowledgebase) Geninformationen: GeneID 7314
Antikörper-Konjugations-Kits
Schlagworte: Anti-Ubiquitin, antibody, antibodies, Antikörper Loading ...
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| Weitere Produkte für dieses Protein:Antibodies
- Anti-Polyubiquitin (K48-linked), clone Apu2, Kat #: VB2900
- Anti-Polyubiquitin (K63-linked), clone Apu3, Kat #: VB2898
- Anti-Polyubiquitin (K63-linked), clone HWA4C4, Kat #: VB2888
- Anti-Polyubiquitin, Lysine 48-Linkage Specific, Kat #: P4480-48.100
- Anti-UBB (N-term), Kat #: WA-AP13217a.20
- Anti-UBB (N-term), Kat #: WA-AP13217a
- Anti-UBB, clone 3C12, Kat #: Pro-30317
- Anti-Ubiquitin, Kat #: A300-317A
- Anti-Ubiquitin, Kat #: 200-401-431
- Anti-Ubiquitin, Kat #: SPC-119B
- more
Enzymes & Proteins
- Bromoethyl ubiquitin, Kat #: VB2918
- Bromoethyl ubiquitin (HA tag), Kat #: VB2926
- Chloroethyl ubiquitin, Kat #: VB2916
- Chloroethyl ubiquitin (HA tag), Kat #: VB2924
- Di-ubiquitin (Ub2, linear), Kat #: VB2568
- Hexa-ubiquitin (Ub6, linear), Kat #: VB2574
- Tetra-ubiquitin (Ub4, linear), Kat #: VB2572
- Tri-ubiquitin (Ub3, linear), Kat #: VB2570
- Ubiquitin, Kat #: VB2252
- Ubiquitin, Kat #: SPB-P3354
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siRNA
ELISA and Assay Kits
Primers
Peptides
Products for: UBB - ubiquitin B
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